- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effect of Whitmania pigra whitman on theAllergic Inflammatory Response
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2008, v.29 no.2, pp.81-95
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(2008). Effect of Whitmania pigra whitman on theAllergic Inflammatory Response. Journal of Korean Medicine, 29(2), 81-95.
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Abstract
Objectives: Whitmania pigra whitman (WP) has been used in herbal medicine to treat various conditions, such as eczema, skin burns and frostbites in herbal medicine. The purpose of this study is was to investigate the effect of WP on anti-allergy mechanism. Methods: To clarify the mechanism, the effect of WP on vascular permeability of rat cutaneous tissue and histamine and cytokines (IL-6, IL-8, TNF-α) released from mast cells were observed. Results: The results were 1.the pretreatment with WP significantly decreased the compound 48/80-induced degranulation and histamine release from RPMC 2.WP did not inhibit the anti-DNP IgE-induced increment of vascular permeability of rat cutaneous tissue 3.WP significantly reduced the PMA plus A23187-induced increment of expression of IL-6, IL-8, and TNF-α in HMC-1 cells. Conclusions: The present study providesevidence that WP acid inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression, and suggest the mechanisms of action. Furthermore, in vivo and in vitro anti-allergic effect of WP suggests a possible therapeutic application of this agent in inflammatory allergic diseases.
- keywords
- Whitmania pigra whitman, HMC-1 cells, histamine, passive cutaneous anaphylaxis (PCA), cytokine
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