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E-ISSN : 2733-4538
This study examined cognitive deficits in patients with Mild Cognitive Impairment(MCI) and sleep apnea syndrome(SAS). Specifically, each of the MCI and control group was divided into high/low SAS risk groups, and they were subjected to two computerized attention tests, including a visual search task and a continuous performance test. In addition, the four groups were subjected to several frontal executive function tests, including a trail making test, a stroop test, and a word fluency test. As a result, while the SAS level significantly affected several attention indices in the MCI group, it did not significantly affected measures of frontal executive function tests. More importantly, SAS had a greater impact on attention deficits in the MCI group than in the control group, whereas it had greater impact on frontal executive functions in the control group than in the MCI group. These results suggest the importance of corresponding evaluation and medical intervention since SAS might act as a deteriorating factor of cognitive functions for both in MCI patients and normal elderlies. Given that there hasn't been many researches in SAS with MCIs in Korea, this study has significance for experimental research with respect to the characteristics of cognitive deficits and SAS risk in MCI patients, Finally, limitations of this study and directions of future research were discussed.
김명선, 강은주, 강연욱, 김현택 (2010). 인지 신경과학과 신경심리학. 시그마프레스.
김성재, 이정희 (2006). 폐쇄성 수면무호흡증 환자에서 신경인지기능 이상과 수면요인과의 관련성. 신경정신의학, 45(4), 295- 306.
김성재, 정재석, 주진형, 이정희 (2008). 경도인지손상 환자에서 야간수면과 전두엽기능의 연관성. 신경정신의학, 47(3), 254-262.
김춘화 (2008). 알츠하이머병 및 경도인지장애 환자의 수면의 질이 인지기능과 삶의 질에 미치는 영향. 경북대학교 석사학위논문.
김효진 (2010). 경증 알츠하이머병 환자에서의 시각적 주의능력 손상과 운전수행. 경북대학교 석사학위논문.
도연정 (2008). 불면증과 수면무호흡 환자의 인지기능 비교. 영남대학교 석사학위논문.
대한치매학회 (2006). 치매 임상적 접근. 아카데미아.
대한노인정신의학회 (2003). 한국형 치매 평가검사. 학지사.
마은주 (2007). 야간 저산소증과 주관적 주간 졸음증이 폐쇄성 수면무호흡증 환자의 인지기능 저하에 미치는 영향. 대한신경과학회지, 25(4), 482-487.
문화식, 이상학 (2008). 노인 연령층의 수면무호흡. 대한내과학회지, 75(2), 156-161.
박영숙 (1998). 심리평가의 실제. 하나의학사.
신경심리연구회 (1998). 뇌손상 환자의 이해를 위한 신경심리평가. 고려의학.
이정희, 김성재, 이동영, 추일한, 김기웅, 윤종철, 우종인 (2007). 정상노인과 경도인지손상 환자에서 수면인자와 신경인지기능의 연관성. 신경정신의학, 46(1), 41-49.
정진영, 장문선, 곽호완 (2008). 성인 ADHD 성향군의 회귀억제와 반응억제 결함. 한국심리학회지: 일반, 27(1), 179-196.
Alchanatis, M., Zias, N., Deligioris, N., Amfilochiou, A., Dionellis, G, & Orphanidou, D. (2005). Sleep apnea-related cognitive deficits and intelligence: an implication of cognitive reserve theory. J Sleep Res, 14, 69-75.
Aloia, M. S., Ilniczky, N., Dio, P., Perlis, M. L., Greenblatt, D. W., & Giles, D. E. (2003). Neuropsychological changes and treatment compliance in older adults with sleep apnea. J Psychosom Res, 54, 71-76.
Ancoli-Israel, S., Kripke, D. F., Klauber, M. R., Mason, W. J., Fell, R., & Kaplan, O. (1991). Sleep-disordered breathing in community- dwelling elderly. Sleep, 14, 486-495.
Anne, D., Isabelle, R., & Jacques, M. (2000). Cognitive deficits associated with sleep apnea syndrome: a proposed neuropsychological test battery. Sleep, 23, 1-13.
Antorelli Incalzi, R., Marra, C., Salvigni, B. L., Petrone, A., Selvaggio, D., et al. (2004). Does cognitive dysfunction conform to a distinctive pattern in obstructive speel apnea syndrome?. J Sleep Res, 13, 79-86.
Arnaiz, E., et al. (2001). Impaired cerebral glucose matabolism and cognitive functioning predict in mild cognitive impairment. Neuroreport, 12(4), 851-855.
Bassuk, S. S., Wypih, D., & Berkman, L. F. (2000). Cognitive impairment and mortality in the community-dwelling elderly. Am J Epodemiol, 151, 676-688.
Bedard, M. A., Montplaisir, J., Richer, F., Rouleau, I., & Malo, J. (1991). Obstructive sleep apnea syndrome: pathogenesis of neuropsychological deficits. J Clin Exp Neuropsychol, 13, 950-964.
Chen, P., Ratcliff, G., Belle, S. H., Cauley, J. A., DeKosky, S. T., & Ganguli, M. (2000). Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented. Neurology, 55, 1847-1853.
Cohen, R. J., & Swerdlik, M. E. (1999). Psychologiccal testing and assessment: An introduction to test and measurement. Mountain View, CA: Mayfield.
Cohen-Zion, .M., Stepnowsky, C., Marler, M., Shochat, T., Kripke, D. F., & Ancoli-Israel S. (2001). Changes in cognitive function associated with sleep disordered breathing in older people. J Am Geriatr Soc, 49, 1622-1627.
Dean, W. B., Lisa, G., Carolyn, W., Alisha, N., & Kevin, M. (2002). The neuropsychological effects of obstructive sleep apnea: a meta-analysis of norm-referenced and case-controlled data. Sleep, 26, 298-307.
Decary, A., Rouleau, I., & Montplaisir, J. (2000). Cognitive deficits associated with sleep apnea syndrome: a proposed neuropsychological test battery. Sleep, 1(23), 369-381.
Denckla, M. B. (1994). Measurement of executive function. Paul H. Brookes Publishing Company, Baltimore, 117-142.
Dempster, F. N. (1992). The rise and fall of the inhibitory mechanism: Toward a unified theory of cognitive development and aging. Developmental Review, 12, 45-75.
De Santi, S., et al. (2001). Hippocampal formation glucose metabolism and volume losses in MCI and AD. Neurobiol Aging, 22(4), 529-539.
Dunbar, K., & MacLeod, C. M. (1984). A horse race of a different color: Stroop interference patterns with transformed words. Journal of experimental Psychology: Human Perception and Performance, 10, 622-639.
Fabrigoule, C., Rouch, I., Taberly, A., Letenneur, L., Commenges, D., Mazaux, J., Orgogozo, J., & Dertiques, J. (1998). Cognitive process in preclinical phase of dementia. Brain, 121, 135-141.
Feldman, H. H., & Jacova, C. (2005). Mild cognitive impairment. Am J Geriatr Psychiatry, 13(8), 645-655.
Findley, L. J., Barth, J. T., Powers, D. C., Wilhoit, S. C., Boyd, D. G., & Suratt, P. M. (1986). Cognitive impairment in patients with obstructive sleep apnea and associated hypoxemia. Chest, 90, 686-690.
Foley, D. J., Monjan, A. A., Brown, S. L., Brown, S. L., Simonsick, E. M., Wallace, R. B., et al. (1995). Sleep complaints among elderly persons: an epodemiologic study of three communities. Sleep, 18, 425-232.
Gosselin, N., Mathieu, A., Mazza, S., Petit, D., Malo, J., & Montplaisir, J. (2006). Attentional deficits in patients with obstructive sleep apnea syndrome: An event-related potential study. Clinical Neuropsychology, 117, 2228-2235.
Graf, P., Uttl, B., & Tuokko, H. (1995). Color-and Picture-word stroop test: Performance changes in old age. Journal of Clinical and Experimental Neuropsychology, 17, 390-415.
Haruo, H., Tomohiko, S., Akira, T., Tomotaka, A., & Toshihiko, I. (2009). Frontal lobe dysfunctions in subjects with mild cognitive impairment. J Neurol, 256, 1570-1571.
Hoch, C. C., Reynolds, C. F., Kupfer, D. J., Houck, P. R., Berman, S. R., & Stack, J. A. (1986). Sleep disordered breathing in normal and pathologic aging. J Clin Psychiatry, 47, 499-503.
Mathieu, A., Mazza, S., Decary, A., Massicotte -Marquez, J., Petit, D., Gosselin, N., Malo, J., & Montplaisir, J. (2008). Effects of obstructive sleep apnea on cognitive function: A comparison between younger and older OSAS patients. Sleep Medicine, 9(2), 112-120.
Mazza, S., Pepin, H. L., Naegele, B., Plante, J., Deschauz, C., & Levy, P. (2005). Most obstructive sleep apnea patients exhibit vigilance and attention deficits on an extended battery of tests. European Respiratory Journal, 25, 75-80.
Naegele, B., Thouvard, V., Pepin, J. L., Levy, P., Bonnet, C., Perret, J. E., et al. (1995). Deficits of cognitive executive functions in patients with sleep apnea syndrome. Sleep, 18, 43-52.
Nikolaus, C. N., Riccardo, A. S., Cordula, M. N., Kathryn, C., & Kingman, P. S. (1999). Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med, 131, 485-491.
Orgogozo, J., Fabrigoule, C., Rouch, I., Amieva, H., & Dartigues, J. (2000). Prediction and early diagnosis of Alzheimer's disease with simple neuropsychological tests. Int J Geriatr Psychopharmacol, 2, 60-67.
Perry, R. J. & Hodges, J. R. (1999). Attention and executive deficits in alzheimer's disease: A clinical review. Brain, 122, 384-404.
Petersen, R. C., et al. (2003). Current concepts in mild cognitive impairment. Arch Neurol, 58(12), 1985-1992.
Pillips, B. A., Berry, D.T., & Lipke-Molby, T. C. (1996). Sleep-disordered breathing in healthy, aged persons: fifth and final year follow-up. Chest, 110, 654-658.
Pillips, B. A., Berry, D. T., Schmitt, F. A., Magan, L. K., Gerhardstein, D. C., & Cook, Y. R. (1992) Sleep-disorderd breathing in the healthy elderly. Clinically significant?. Chest, 101, 345-349.
Rapp, M. A., & Reischies, F. M. (2005). Attention and executive control predict Alzheimer disease in late life. Results from the Berlin Aging Study(BASE). Am J Geriatr Psychiatry, 13, 134-141.
Raz, N. (2000). Aging of the brain and its impact on cognitive performance: Intergration of structural and functional findings. In F. I. M. Craik & T. A. Salthouse (Eds.), Handbook of Aging and Cognition II. Mahwah, NJ: Erlbaum.
Redline, S., Strauss, M. E., Adams, N., Winters, M., Roebuck, T., Spray, K., et al. (1997). Neuropsychological function in mild sleep- disordered breathing. Sleep, 20, 160-167.
Ritchie, K., Artero, S., & Touchon, J. (2001). Classification criteria for mild cognitive impairment-a population-based validation study. Neurology, 56, 37-42.
Salorio, C. F., White, D. A., Piccirillo, J., Duntley, S. P., & Uhles, M. L. (2002). Learning, memory, and executive control in individual with obstructive sleep apnea syndrome. Journal of Clinical and Experimental Neuropsychology, 24(1), 93-100.
Saunamaki, T., & Jehkinen, M. (2007). A review of executive functionsin obstructive sleep apnea syndrome. Acta Neurogica Scandinavica, 115, 1-11.
Verstraeten, E., Cluydis, R., Pevemagie, D., & Hoffmann, G. (2004). Executive function in sleep apnea: Controlling for attentional capacity in assessing executive attention. Sleep, 27, 685-693.
Young, T., Shahar, E., Nieto, F. J., Redline, S., Newman, A. B., Gottlieb, D. J., Walsleben, J. A., Finn, L., Enright, P., & Samet, J. M. (2002). Predictore of sleep-disordered breathing in community-dwelling adult: the Sleep heart health study. Arch Intern Med, 162, 893-900.
Zhang, X., Wang, Y., Li, S., Huang, X., & Cui, L. (2002). Early detection of cognitive impairment in patient with obstructive sleep apnea syndrome: an event-related potential study. Meurosci Lett, 7, 99-102.