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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Characterization of the Interaction between White Ginseng Extract and Selegiline Using Triple Quadrupole-Mass Spectrometry

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2019, v.10 no.2, pp.61-62
Cho Pil Joung (Kyungpook National University)
Liu Kwang-Hyeon (Kyungpook National University)
Song Im-Sook (Kyungpook National University)
Song Kyung-Sik (Kyungpook National University)
Lee Sangkyu (Kyungpook National University)
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Korean ginseng (Panax ginseng Meyer) is a traditional herb used across the world to treat various diseases. Although, red ginseng is this herb’s most famous product and has demonstrated diverse pharmacological activities, white ginseng (WG) is another ginseng product that is made fresh and individually regulated in Eastern Asia. Red and white ginseng show different characteristics due to distinct processing steps despite originating from the same plant, and the drug interactions induced by WG have not been well documented. Selegiline is a selective monoamine oxidase (MAO) inhibitor used as an antidyskinetic and antiparkinsonian agent. Here we developed a quantification method for selegiline in mouse plasma using a C8 stationary phase in triple quadrupole-mass spectrometry (LC-MS/MS) with multiple reaction monitoring (MRM). The validated LC-MS/MS method was successfully applied to determine the potential interaction with WG extract (0.1 g/kg/day) pre-administered for 4 weeks. The AUC 0-240 min of selegiline was altered due to a decrease in the absorption of selegiline with repeated administration of WG extract.

White ginseng extract, LC-MS/MS, selegiline, herb-drug interaction



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