- P-ISSN 2233-4203
- E-ISSN 2093-8950
- Apply for Authority
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI
Article Detail
Home > Article Detail
Evaluation of the inhibitory effect of Gynostemma pentaphyllum extracts on CYP450 enzyme activities using LC-MS/MS
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2023, v.14 no.3, pp.116-119
https://doi.org/10.5478/MSL.2023.14.3.116
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Minzu University of China)
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Minzu University of China)
(Hanyang University)
Yu,
J. S., Ji,
Y. S., Jo,
S. Y., Piao,
X., &
Yoo,
H.
H.
(2023). Evaluation of the inhibitory effect of Gynostemma pentaphyllum extracts on CYP450 enzyme activities using LC-MS/MS. Mass Spectrometry Letters, 14(3), 116-119, https://doi.org/10.5478/MSL.2023.14.3.116
- Downloaded
- Viewed
Abstract
Gynostemma pentaphyllum (Thunb.) Makino extract, a natural product with a history of traditional use, has gained attention for its potential health benefits. This study aimed to investigate its effects on key cytochrome P450 (CYP) enzymes using LC-MS/MS. Human liver microsomes and cDNA-expressed CYP2C8, CYP2C9, CYP2C19, and CYP3A4 supersomes were employed. Enzyme activity was assessed based on the formation of CYP-specific marker metabolites. The resulting data showed that the extract exhibited inhibitory effects on CYP2C8, CYP2C9, CYP2C19, and CYP3A4. Thus, G. pentaphyllum extract may influence the pharmacokinetics of drugs metabolized by CYP2C8, CYP2C9, CYP2C19, and CYP3A4. These find- ings emphasize the importance of considering potential herb-drug interactions when incorporating this extract into therapeutic regimens or dietary supplements.
- keywords
- Gynostemma pentaphyllum, cytochrome P450, herb-drug interaction, LC-MS/MS
- Submission Date
- 2023-09-28
- Revised Date
- 2023-09-29
- Accepted Date
- 2023-09-28
Other articles from this issue
- Advances and Applications of Mass Spectrometry Imaging in Neuroscience: An Overview
- GC-MS Analysis of Ricinus communis, Pongamia pinnata, Datura metal, Azadirachta indica, Acalypha indica (leaf) Extract Using Methanol Extraction
- LC-MS/MS-based Quantification of Ten Neurotransmitters in Rat Limbic System and Serum: Application to Chronic Unpredictable Mild Stress- Induced Depression Rats
- Quantification of Three Prohibited Anabolic-Androgenic Steroids in Equine Urine using Gas Chromatography-Tandem Mass Spectrometry
- First Example of Monometallic Palladium(II) Compound with Trans-Chelating Tridentate Ligand: Synthesis, Crystal Structure, and Characterizations
- Evaluation of the inhibitory effect of Gynostemma pentaphyllum extracts on CYP450 enzyme activities using LC-MS/MS
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.