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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Gold Nanostructure-Based Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for Analysis of Small Biomolecules

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2024, v.15 no.1, pp.26-39
Cho Hye-Sun (Dongguk University-Seoul)
Seo Tae Hoon (Korea Institute of Industrial Technology)
Park Ji Hun (Ewha Womans University)
Kim Young-Kwan (Dongguk University-Seoul)
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Gold nanostructures (Au NSs) are useful and interesting matrices for mass spectrometric analysis of various biomol-ecules based on organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF-MS). Au NSs pro-vide high efficiency and versatility in LDI-TOF-MS analysis based on their well-established synthesis and surface functionalization, large surface area, high laser absorption capacity, and photothermal conversion efficiency. Therefore, Au NSs based LDI-TOF-MS can be a facile, functional, and efficient analytical method for important small biomolecules owing to its simple preparation, rapid analysis, salt-tolerance, signal reproducibility, and quantitative analysis. This review chronologically summarizes the important advance of Au NSs-based LDI-TOF-MS platforms in terms of in-depth mechanism, signal enhance-ment, quantitative analysis, and disease diagnosis.

gold nanostructure, nanohybrid, laser, mass spectrometry, small molecules

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Mass Spectrometry Letters