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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN2233-4203
  • E-ISSN2093-8950
  • ESCI, SCOPUS, KCI

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Optimization of Ceramide Analysis Method Using LC-MS in Cosmetics

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2024, v.15 no.1, pp.49-53
https://doi.org/10.5478/MSL.2024.15.1.49
Su-Jin Park (Korea Basic Science Institute (KBSI))
Hee-Jin Yoo (Korea Basic Science Institute (KBSI))
Duck-Hyun Kim (Korea Basic Science Institute (KBSI))
Ji-Won Park (Korea Basic Science Institute (KBSI))
Eunji Jeon (Korea Basic Science Institute (KBSI))
Abhik Mojumdar (Korea Basic Science Institute (KBSI))
Kun Cho (Korea Basic Science Institute (KBSI))
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Abstract

Ceramide is a lipid in which sphingoid bases and fatty acids are linked by amide bonds. As a marker of skin disease in the human stratum corneum, its disease-causing and therapeutic effects have been partially confirmed, and it is therefore an important element in commercially available cosmetic formulations. However, structural diversity caused by differences in the chain length, number, and location of hydroxyl groups makes quality control difficult. In this study, a method was established to separate different ceramide species using reversed-phase LC-MS/MS and thus enable qualitative evaluation. Separation of four standards was achieved within a short retention time, and the accuracy and sensitivity of the method were demonstrated by the low limit of detection (LOD) calculated based on the calibration curve showing linearity, with R 2 > 0.994. After verification of reproducibility and reliability through intra- and inter-day analyses, the efficiency of the method was confirmed through analysis of commercial cosmetic raw materials.

keywords
Ceramide, Cosmetics, LC-MS/MS


투고일Submission Date
2023-12-29
수정일Revised Date
2024-02-26
게재확정일Accepted Date
2024-02-26
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Mass Spectrometry Letters