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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
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  • P-ISSN2233-4203
  • E-ISSN2093-8950
  • ESCI, SCOPUS, KCI

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Determination of the PDE-5 Inhibitors and Their Analogues by GC-MS and TMS Derivatization

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2012, v.3 no.1, pp.15-17
https://doi.org/10.5478/MSL.2012.3.1.015
Jaesung Pyo (National Forensic Service)
Heesang Lee (National Forensic Service)
Yujin Park (National Forensic Service)
Jiyeong Jo (National Forensic Service)
Yonghoon Park (National Forensic Service)
Sanggil Choe (National Forensic Service)
Miyoung Lee (Health Research Institute)
Jaesin Lee (National Forensic Service)
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Abstract

Eighteen of the PDE-5 inhibitors and their analogues were analyzed using GC-EI-MS. Fourteen of them could beidentified by simple GC-MS method without derivatization, but hydroxyhongdenafil, hydroxyvardenafil, xanthoanthrafil andmirodenafil could not be identified without derivatization for the high polarity due to the presence of hydroxyl groups. N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), widely used trimethylsilyl (TMS) derivatizing reagents, were used to improve the sensitivity of the hydroxylated analogues. And the analytes could be identified by GC-MS after the derivatization.

keywords
PDE-5 inhibitor, GC-MS, BSTFA, MTBSTFA, TMS derivatization


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투고일Submission Date
2011-05-02
수정일Revised Date
2012-02-07
게재확정일Accepted Date
2012-02-23
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Mass Spectrometry Letters