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- E-ISSN 2093-8950
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Determination of the PDE-5 Inhibitors and Their Analogues by GC-MS and TMS Derivatization
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2012, v.3 no.1, pp.15-17
https://doi.org/10.5478/MSL.2012.3.1.015
(National Forensic Service)
(National Forensic Service)
(National Forensic Service)
(National Forensic Service)
(National Forensic Service)
(National Forensic Service)
(Health Research Institute)
(National Forensic Service)
(National Forensic Service)
(National Forensic Service)
(National Forensic Service)
(National Forensic Service)
(National Forensic Service)
(Health Research Institute)
(National Forensic Service)
Pyo,
J., Lee,
H., Park,
Y., Jo,
J., Park,
Y., Choe,
S., Lee,
M., &
Lee,
J.
(2012). Determination of the PDE-5 Inhibitors and Their Analogues by GC-MS and TMS Derivatization. Mass Spectrometry Letters, 3(1), 15-17, https://doi.org/10.5478/MSL.2012.3.1.015
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Abstract
Eighteen of the PDE-5 inhibitors and their analogues were analyzed using GC-EI-MS. Fourteen of them could beidentified by simple GC-MS method without derivatization, but hydroxyhongdenafil, hydroxyvardenafil, xanthoanthrafil andmirodenafil could not be identified without derivatization for the high polarity due to the presence of hydroxyl groups. N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), widely used trimethylsilyl (TMS) derivatizing reagents, were used to improve the sensitivity of the hydroxylated analogues. And the analytes could be identified by GC-MS after the derivatization.
- keywords
- PDE-5 inhibitor, GC-MS, BSTFA, MTBSTFA, TMS derivatization
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- Submission Date
- 2011-05-02
- Revised Date
- 2012-02-07
- Accepted Date
- 2012-02-23
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