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- E-ISSN 2093-8950
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Tertiary Matrices for the Analysis of Polyethylene Glycols Using MALDI-TOF MS
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2014, v.5 no.2, pp.49-51
https://doi.org/10.5478/MSL.2014.5.2.49
(Chungnam National University)
(Chungnam National University)
(Chungnam National University)
(Chungnam National University)
(Chungnam National University)
Hong,
J., Kim,
T., &
Kim,
J.
(2014). Tertiary Matrices for the Analysis of Polyethylene Glycols Using MALDI-TOF MS. Mass Spectrometry Letters, 5(2), 49-51, https://doi.org/10.5478/MSL.2014.5.2.49
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Abstract
The effectiveness of tertiary matrices composed of the combination of three common matrices (dihydrobenzoic acid(DHB), α-cyano-4-hydroxycinnamic acid (CHCA), and sinapinic acid (SA)) was compared with that of single or binary matricesin the analysis of polyethylene glycol (PEG) polymers ranging from 1400 to 10000 Da using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). A tertiary matrix of 2,5-DHB+CHCA+SA was the mosteffective in terms of S/N ratios. CHCA and CHCA+SA produced the highest S/N ratios among the single matrices and thebinary matrices, respectively. The improvement observed when using a tertiary matrix in analyses of PEG polymers by MALDITOFMS is believed to be due to the uniform morphology of the MALDI sample spots and synergistic effects arising from themixture of the three matrix materials.
- keywords
- MALDI-TOF MS, tertiary matrix, polyethylene glycols, 2, 5-dihydrobenzoic acid, α-cyano-4-hydroxycinnamic acid, sinapinic acid
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- Submission Date
- 2014-05-11
- Revised Date
- 2014-06-02
- Accepted Date
- 2014-06-05
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