- P-ISSN 2233-4203
- E-ISSN 2093-8950
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI, SCOPUS, KCI
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Degradation Efficiency and Characterization of Lincomycin by Electron Beam Irradiation
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2014, v.5 no.3, pp.89-93
https://doi.org/10.5478/MSL.2014.5.3.89
(Kyonggi University)
(Kyonggi University)
(Kyonggi University)
(Kyonggi University)
(Kyonggi University)
Ham,
H., Cho,
H., &
Myung,
S.
(2014). Degradation Efficiency and Characterization of Lincomycin by Electron Beam Irradiation. Mass Spectrometry Letters, 5(3), 89-93, https://doi.org/10.5478/MSL.2014.5.3.89
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Abstract
Lincomycin is one of the major species among the Pharmaceuticals and Personal Care Products (PPCPs) detectedfrom the four major rivers in Korea. The structure characterization was performed of six degradation products of lincomycinformed under the irradiation of electron beam, and the degradation efficiency as a function of the various irradiation dose andsample concentration was investigated. Electron beam (10 MeV, 0.5 mA and 5 kW) experiments for the structural characterizationof degradation products that are fortified with lincomycin, were performed at the dose of 10 kGy. The separation of degradationproducts and lincomycin was carried out using a C18 column (2.1×100 mm, 3.5 μm), using gradient elution with 20 mMammonium acetate and acetonitrile. The structures of six degradation products of lincomycin were proposed by interpretation ofmass spectra and chromatograms by LC-MS/MS. The mass fragmentation pathways of mass spectra in tandem mass spectrometrywere also proposed. Experiments were performed of the degradation efficiency as a function of the irradiation dose intensityand the initial concentration of lincomycin in an aqueous environment. In addition, increased degradation efficiency wasobserved with a higher dose of electron beam and lower concentration.
- keywords
- Degradation products, Lincomycin, Electron beam, LC-MS/MS
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- Submission Date
- 2014-07-17
- Revised Date
- 2014-09-10
- Accepted Date
- 2014-09-13
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