- P-ISSN 2233-4203
- E-ISSN 2093-8950
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI, SCOPUS, KCI
Article Detail
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Analytical Techniques Using ICP-MS for Clinical and Biological Analysis
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2015, v.6 no.4, pp.85-90
https://doi.org/10.5478/MSL.2015.6.4.85
(Dankook University)
(Dankook University)
(Dankook University)
Ko,
J., &
Lim,
H.
(2015). Analytical Techniques Using ICP-MS for Clinical and Biological Analysis. Mass Spectrometry Letters, 6(4), 85-90, https://doi.org/10.5478/MSL.2015.6.4.85
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Abstract
This article reviews recent analytical techniques using inductively coupled plasma-mass spectrometry (ICP-MS) immunoassay for clinical and bio analysis. We classified the techniques into two categories, direct and indirect analysis, which depend upon a guideline of whether tagging materials are used or not. Direct analysis is well known, and generally used in con-junction with various other techniques, such as laser ablation, chromatographic separations, etc. Recently, indirect analysis using tagging elements has intensively been discussed because of its importance in future applications to bio and clinical analysis, including environmental and food industries. The method has shown advantages of multiplex detection, excellent sensitivity, and short analysis time owing to signal amplification and magnetic separation. Now, it expands the application field from small bio-molecules to large cells.
- keywords
- ICP-MS, Nanoparticle, Immunoassay, Particle tagging
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- Submission Date
- 2015-09-17
- Revised Date
- 2015-11-23
- Accepted Date
- 2015-11-30
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