- P-ISSN 2233-4203
- E-ISSN 2093-8950
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI, SCOPUS, KCI
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UHPLC-ESI-qTOF-MS Analysis of Cyclopeptide Alkaloids in the Seeds of Ziziphus jujuba var. spinosa
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2016, v.7 no.2, pp.45-49
https://doi.org/10.5478/MSL.2016.7.2.45
(Seoul National University)
(Kyung Hee University)
(Seoul National University)
(Seoul National University)
(Kyung Hee University)
(Seoul National University)
(Seoul National University)
Kang,
K. B., Jang,
D. S., Kim,
J., &
Sung,
S.
H.
(2016). UHPLC-ESI-qTOF-MS Analysis of Cyclopeptide Alkaloids in the Seeds of Ziziphus jujuba var. spinosa. Mass Spectrometry Letters, 7(2), 45-49, https://doi.org/10.5478/MSL.2016.7.2.45
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Abstract
An UHPLC-ESI-qTOF-MS analytical method was developed for cyclopeptide alkaloids in the seeds of Ziziphus jujuba var. spinosa (Semen Ziziphi Spinosae), which is a commonly used herb in Chinese and Korean traditional medicines. Considering the basicity of cyclopeptide alkaloids, a specific separation method was developed for an UHPLC system. The compounds were detected by DAD and ESI-qTOF-MS, and their fragmentation patterns were also acquired by MSE technologies. Peak-picking of major compounds was performed with nine previously isolated compounds and two reference standard compounds. Tandem MS fragmentation behaviors of type-Ia and -Ib cyclopeptide alkaloids were investigated with the acquired data to develop a strategy for dereplication of other cyclopeptide alkaloid compounds in Z. jujuba var. spinosa. Two more cyclopeptide alkaloids were tentatively identified with UHPLC–ESI-qTOF-MS using this method.
- keywords
- Cyclopeptide alkaloids, UHPLC–ESI-qTOF-MS, Ziziphus jujuba var. spinosa
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- Submission Date
- 2016-05-11
- Revised Date
- 2016-06-20
- Accepted Date
- 2016-06-21
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