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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN2233-4203
  • E-ISSN2093-8950
  • ESCI, SCOPUS, KCI

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

MS-Based Technologies for the Study of Site-Specific Glycosylation

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2017, v.8 no.4, pp.69-78
https://doi.org/10.5478/MSL.2017.8.4.69
Unyong Kim (Chungnam National University, GLYCAN Co., Ltd.,)
Myung Jin Oh (Chungnam National University)
Jua Lee (Chungnam National University)
Hee Yeon Hwang (Chungnam National University)
Hyun Joo An (Chungnam National University)
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Abstract

Glycosylation, which is one of the most common post-translation modification (PTMs) of proteins, plays a variety of crucial roles in many cellular events and biotherapeutics. Recent advances have led to the development of various analytical methods employing a mass spectrometry for glycomic and glycoproteomic study. However, site-specific glycosylation analysis is still a relatively new area with high potential for technologies and method development. This review will cover current MSbased workflows and technologies for site-specific mapping of glycosylation ranging from glycopeptide preparation to MS analysis. Bioinformatic tools for comprehensive analysis of glycoprotein with high-throughput manner will be also included.

keywords
Glycosylation, Glycopeptide, Mass Spectrometry, Site-specific mapping, Bioinformatics


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투고일Submission Date
2017-11-17
수정일Revised Date
2017-12-18
게재확정일Accepted Date
2017-12-18
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