- P-ISSN 2233-4203
- E-ISSN 2093-8950
In this study, matrix-assisted laser desorption/ionization (MALDI) was applied to the TEMPO-assisted FRIPS for the first time. We found that 3-HPA is the optimal matrix for the analysis of p-TEMPO-Bz-Sc-peptides, which gives minimal precursor fragmentations. MALDI-TOF/TOF experiments on p-TEMPO-Bz-Sc-peptides yielded mainly [a n +H] + , [z n +H] + , and [y n ] + -type products, indicating that radical-driven peptide fragmentation occurs in MALDI-TOF/TOF-MS.
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