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- E-ISSN 2093-8950
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In vitro Metabolism of Methallylescaline in Human Hepatocytes Using Liquid Chromatography-High Resolution Mass Spectrometry
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2018, v.9 no.3, pp.86-90
https://doi.org/10.5478/MSL.2018.9.3.86
(The Catholic University of Korea)
(Yeungnam University)
(The Catholic University of Korea)
(National Forensic Service)
(National Forensic Service)
(The Catholic University of Korea)
(Yeungnam University)
(The Catholic University of Korea)
(National Forensic Service)
(National Forensic Service)
(The Catholic University of Korea)
Kim,
S., Kim,
J., Kim,
D. K., Lee,
J., In,
S., &
Lee,
H.
S.
(2018). In vitro Metabolism of Methallylescaline in Human Hepatocytes Using Liquid Chromatography-High Resolution Mass Spectrometry. Mass Spectrometry Letters, 9(3), 86-90, https://doi.org/10.5478/MSL.2018.9.3.86
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Abstract
Methallylescaline, 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethanamine, is a new psychoactive substance with potent agonist of 5-HT receptor, but there is little information on its pharmacological effect, metabolism, and tox- icity. It is necessary to characterize the metabolic profiling of methallylescaline in human hepatocytes using liquid chromatogra- phy-high resolution mass spectrometry. Methallylescaline was metabolized to three hydroxy-methallylescaline (M1-M3) and dihydroxy-methallylescaline (M4) via hydroxylation in human hepatocytes. CYP2D6, CYP2J2, CYP1A2, and CYP3A4 enzymes were responsible for the metabolism of methallylescaline. The metabolites as well as methallylescaline would be used for monitoring the abuse of methallylescaline,
- keywords
- methallylescaline, in vitro metabolism, liquid chromatography-high resolution mass spectrometry
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- Submission Date
- 2018-09-07
- Revised Date
- 2018-09-28
- Accepted Date
- 2018-09-28
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