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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Multi-class Analysis of Exposure Chemicals in Deciduous Teeth by Liquid Chromatography-Mass Spectrometry: Preliminary Studies on Sample Preparation Methods

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2018, v.9 no.4, pp.110-114
https://doi.org/10.5478/MSL.2018.9.4.110
Lee Yujin (Hankuk University of Foreign Studies)
Seo Eunji (Hankuk University of Foreign Studies)
Park Jun Young (Hankuk University of Foreign Studies)
Bae Kwang-Hak (Apple tree Dental Hospital)
Lee Jaeick (Korea Institute of Science and Technology,)
Cha Sangwon (Hankuk University of Foreign Studies)
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Abstract

Since accumulation of chemicals in deciduous teeth can occur from the second trimester of fetal development to shedding, a deciduous tooth has been considered as an attractive biomatrix for estimating individual chemical exposures recently. Therefore, detection of organic chemicals from teeth has received an increasing attention in exposomics research. Most previous studies on organic chemical analysis of teeth not only focused on a few targeted chemicals but also ignored potential contaminants from an enamel surface or a dental pulp. Recently, our group started developing a multi-class organic analysis method for deciduous teeth and tried to find a proper incubation condition of tooth materials. Our results showed that incubation with methanolic HCl provided the best performance among tested.

keywords
exposomics, deciduous teeth, sample preparation, dentin, enamel


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Submission Date
2018-12-17
Revised Date
2018-12-18
Accepted Date
2018-12-18
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