바로가기메뉴

본문 바로가기 주메뉴 바로가기

logo

메뉴

불면증 인지행동치료가 주간 과각성 및 불면증상에 미치는 효과-예비연구

Effects of Cognitive-Behavioral Therapy for Insomnia on sleep and daytime hyperactivity -A Preliminary Study

초록

본 연구는 불면증 인지행동치료(Cognitive Behavioral Therapy of Insomnia: CBT-I)의 효과를 생리심리학적 관점에서 규명하기 위해 시행되었다. 연구대상은 다른 정신과적 장애나 수면무호홉증, 일주기리듬 수면장애를 충족하지 않으며 수면의 어려움을 시사하는 불면증 심각도 척도(Insomnia Severity index: ISI) 점수가 15점 이상, 수면의 질(Pittsburgh Sleep Quality Index: PSQI)점수가 6점 이상을 나타낸 참가자들이며, 이들을 치료집단과 대기통제집단에 무선할당 하였다. 8명의 치료집단은 6회기의 불면증 인지행동치료를 받았고, 9명의 대기통제집단은 6주간 아무런 처지를 받지 않았다. CBT-I의 효과검증을 위해 치료집단과 대기통제집단의 치료 전과 후에 휴식기 정량적 뇌파, 심박변이도를 측정하였고, 수면 관련 자기보고 척도를 실시하였으며, 스마트 웨어러블 기기 및 수면일지 작성을 통해 수면 양상을 파악하였다. 연구 결과, 치료집단은 대기통제집단보다 고주파 대역인 Beta 주파수 대역의 파워감소, 수면 관련 자기보고 척도 점수의 감소, 수면 효율성과 수면만족도가 증가하였음을 확인하였다. 본 연구는 불면증 인지행동치료의 효과를 신경생리학적 과각성 지표인 고주파 대역의 파워 감소를 통해 확인하였고, 기존의 불면증 인지행동치료 효과 검증에서 사용되는 자기보고식 측정 뿐 만 아니라, 객관적 자료인 스마트 웨어러블 기기의 수면 정보를 활용하였다는 점에서 의의가 있다.

keywords
Insomnia, Cognitive Behavioral Therapy of Insomnia, qEEG, hyper-arousal, Smart Wearable Device, 불면증, 불면증 인지행동치료, 휴식기 뇌파, 과각성, 스마트 웨어러블 기기

Abstract

This study demonstrated the physiological and psychological effects of Cognitive Behavioral Therapy for Insomnia (CBT-I). CBT-I is an evidence-based psychotherapy that deals with bad sleep habits and behaviors, dysfunctional beliefs, and attitudes toward sleep. In this study, participants who did not have other mental illnesses or sleep problem related to sleep apnea of circadian rhythm sleep disorder and showed an insomnia severity index of 15 or more and Pittsburgh sleep quality index of 6 or more were recruited. They were randomly assigned to a treatment or a wait-list control group. The treatment group received six 60-min sessions of CBT-I (n=8), while the wait-list control group received not any psychological intervention(n=9). To verify the effectiveness of CBT-I, we measured the resting quantitative EEG and heart rate variability, insomnia symptom by self-report sleep scale and sleep monitoring data by smart wearable devices and sleep diary before and after treatment Results showed significantly decreased Beta power, sleep scale score and increased Theta power, WASO(Wake After Sleep Onset), SE(Sleep Efficiency), Sleep satisfaction. This study found that daytime hyperactivity can be reduced by psychological intervention. In addition, it is significant thatl the improvement of sleep problem were observed by using not only subjective self-report but also objective measures such as resting quantitative EEG and smart wearable devices.

keywords
Insomnia, Cognitive Behavioral Therapy of Insomnia, qEEG, hyper-arousal, Smart Wearable Device, 불면증, 불면증 인지행동치료, 휴식기 뇌파, 과각성, 스마트 웨어러블 기기

참고문헌

1.

김무경, 구훈정, 권정혜, 한진규 (2014). 한국판 글라스고 수면 노력 척도의 타당화 연구. 인지행동치료, 14(2), 319-337.

2.

김성재 (2012). 20-39세 성인에서 한국판 아침형-저녁형 설문(MEQ-K)의 표준화 연구. 강원대학교 대학원 박사학위 논문.

3.

민성순, 이은형, 김종득, 이상희, 권오순, 권정남, 김영균 (2006). 심전도 이상 소견의 심박변이도(HRV)에 관한 고찰. 대한한방내과학회지, 27(4), 798-810.

4.

성형모, 김정범, 박영남, 배대석, 이선희, 안현의 (2008). 한국어판 백 우울 설문지 2판의 신뢰도 및 타당도 연구. 생물치료정신의학, 14(2); 201-212.

5.

심영우, 양동인, 김남현, 김덕원 (2010). 자세와 수면 박탈이 심박변이도에 미치는 영향. 전자공학회, 47(2); 43-49.

6.

유은승, 고영건, 성기혜, 권정혜 (2009). 한국판 수면에 대한 역기능적 신념 및 태도 척도에 대한 타당화 연구. Korean Journal of Clinical Psychology, 28(1), 309-320.

7.

육성필, 김중술 (1997). 한국판 Beck Anxiety Inventory 의 임상적 연구: 환자군과 비환자군의 비교. Korean Journal of Clinical Psychology, 16(1), 185-197.

8.

장창현, 김석현, 오동훈 (2013). 불면증의 인지행동치료. Hanyang Med Reviews, 33, 210-215.

9.

정지현, 이병찬, 문혜진, 조용원 (2013). 불면증 인지행동치료의 효과와 이와 관련된 인자. 수면, 10(2), 39-44.

10.

조영은, 권정혜 (2012). 불면증에 대한 스트레스와 인지과정의 통합 모형 검증. Korean Journal of Clinical Psychology, 31(1), 135-150.

11.

최승원, 조혜현, 허지언, 김기성, 정선용 (2012). 뉴로피드백 입문. 시그마프레스.

12.

최희정, 김성재, 김범종, 김인자 (2012). 수면장애 연구와 실무를 위한 한국어 자가보고 수면 측정도구. 재활간호학회지, 15(1), 1-10.

13.

Ahmadi, N., Chung, S. A., Gibbs, A., & Shapiro, C. M. (2008). The Berlin questionnaire for sleep apnea in a sleep clinic population: relationship to polysomnographic measurement of respiratory disturbance. Sleep and Breathing, 12(1), 39-45.

14.

Aikens, J. E., & Rouse, M. E. (2005). Help-seeking for insomnia among adult patients in primary care. The Journal of the American Board of Family Practice, 18(4), 257-261.

15.

Araújo, T., Jarrin, D. C., Leanza, Y., Vallières, A., & Morin, C. M. (2017). Qualitative studies of insomnia: Current state of knowledge in the field. Sleep Medicine Reviews, 31, 58-69.

16.

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author

17.

Anderson, K. N. (2018). Insomnia and cognitive behavioural therapy-how to assess your patient and why it should be a standard part of care. Journal of thoracic disease, 10(Suppl 1), S94.

18.

Backhaus, J., Hohagen, F., Voderholzer, U., & Riemann, D. (2001). Long-term effectiveness of a short-term cognitive-behavioral group treatment for primary insomnia. European Archives of Psychiatry and Clinical Neuroscience, 251(1), 35-41.

19.

Backhaus, J., Junghanns, K., Broocks, A., Riemann, D., & Hohagen, F. (2002). Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia. Journal of psychosomatic research, 53(3), 737-740.

20.

Belleville, G. (2010). Mortality hazard associated with anxiolytic and hypnotic drug use in the National Population Health Survey. The Canadian Journal of Psychiatry, 55(9), 558-567.

21.

Birling, Y., Wang, J., Li, G., Wu, E., Yu, Z., Feng, Y., & Wu, Y. (2018). Culturally Adapted CBTI for Chinese Insomnia Patients: a One-Arm Pilot Trial. International journal of behavioral medicine, 25(3), 331-340.

22.

Bonnet, M. H., &Arand, D. L. (1998). Heart rate variability in insomniacs and matched normal sleepers. Psychosomatic medicine, 60(5), 610-615.

23.

Bonnet, M. H., & Arand, D. L. (2010). Hyperarousal and insomnia: state of the science. Sleep medicine reviews, 14(1), 9-15.

24.

Bootzin, R. R., & Nicassio, P. M. (1978). Behavioral treatments for insomnia. New York, NY: Academic Press

25.

Broomfield, N. M., & Espie, C. A. (2005). Towards a valid, reliable measure of sleep effort. Journal of sleep research, 14(4), 401-407.

26.

Buysse, D. J., Ancoli-Israel, S., Edinger, J. D., Lichstein, K. L., & Morin, C. M. (2006). Recommendations for a standard research assessment of insomnia. Sleep, 29(9), 1155- 1173.

27.

Buysse, D. J., Germain, A., Hall, M. L., Moul, D. E., Nofzinger, E. A., Begley, A., ... &Kupfer, D. J. (2008). EEG spectral analysis in primary insomnia: NREM period effects and sex differences. Sleep, 31(12), 1673-1682.

28.

Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Research, 28(2), 193-213.

29.

Camm, A. J., Malik, M., Bigger, J. T., Breithardt, G., Cerutti, S., Cohen, R. J., ... &Lombardi, F. (1996). Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. European heart journal, 17(3), 354-381.

30.

Carlsten, A., & Waern, M. (2009). Are sedatives and hypnotics associated with increased suicide risk of suicide in the elderly?. BMC geriatrics, 9(1), 20

31.

Carney, C. E., Edinger, J. D., Morin, C. M., Manber, R., Rybarczyk, B., Stepanski, E. J., ... & Lack, L. (2010). Examining maladaptive beliefs about sleep across insomnia patient groups. Journal of psychosomatic research, 68(1), 57-65.

32.

Cellini, N., de Zambotti, M., Covassin, N., Sarlo, M., & Stegagno, L. (2014). Working memory impairment and cardiovascular hyperarousal in young primary insomniacs. Psychophysiology, 51(2), 206-214.

33.

Cervena, K., Dauvilliers, Y., Espa, F., Touchon, J., Matousek, M., Billiard, M., & Besset, A. (2004). Effect of cognitive behavioural therapy for insomnia on sleep architecture and sleep EEG power spectra in psychophysiological insomnia. Journal of Sleep Research, 13(4), 385- 393.

34.

Chae, K. Y. (2007). Physiology of sleep. Korean J Pediatr, 50(8), 711.

35.

Cheung, J. M., Bartlett, D. J., Armour, C. L., Glozier, N., & Saini, B. (2014). Insomnia patients’ help-seeking experiences. Behavioral Sleep Medicine, 12(2), 106-122.

36.

Cho. Y. W., Lee, J. H., Son, H. K., Lee, S. H., Shin, C., & Johns, M. W. (2011). The reliability and validity of the Korean version of the Epworth sleepiness scale. Sleep and Breathing, 15(3), 377-384.

37.

Cho, Y. W., Song, M. L., & Morin, C. M. (2014). Validation of a Korean version of the insomnia severity index. Journal of Clinical Neurology, 10(3), 210-215.

38.

Coates, T. J., Killen, J. D., George, J., Marchini, E., Silverman, S., Hamilton, S., & Thoresen, C. E. (1982). Discriminating good sleepers from insomniacs using all-night polysomnograms conducted at home. The Journal of Nervous and Mental Disease, 170(4), 224-230.

39.

Corsi-Cabrera, M., Figueredo-Rodríguez, P., del Río-Portilla, Y., Sánchez-Romero, J., Galán, L., & Bosch-Bayard, J. (2012). Enhanced frontoparietal synchronized activation during the wake-sleep transition in patients with primary insomnia. Sleep, 35(4), 501-511.

40.

Colombo, M. A., Ramautar, J. R., Wei, Y., Gomez-Herrero, G., Stoffers, D., Wassing, R., ... & Van Someren, E. J. (2016). Wake high-density electrencephalographic spatiospectral signatures of insomnia. Sleep, 39(5), 1015-1027

41.

Corsi-Cabrera, M., Figueredo-Rodríguez, P., del Río-Portilla, Y., Sánchez-Romero, J., Galán, L., & Bosch-Bayard, J. (2012). Enhanced frontoparietal synchronized activation during the wake-sleep transition in patients with primary insomnia. Sleep, 35(4), 501-511.

42.

Covassin, N., de Zambotti, M., Sarlo, M., Tona, G. D. M., Sarasso, S., & Stegagno, L. (2011). Cognitive performance and cardiovascular markers of hyperarousal in primary insomnia. International Journal of Psychophysiology, 80(1), 79-86.

43.

Cunnington, D., Junge, M. F., & Fernando, A. T. (2013). Insomnia: prevalence, consequences and effective treatment. Medical Journal of Australia, 199, S36-S40.

44.

De Gage, S. B., Moride, Y., Ducruet, T., Kurth, T., Verdoux, H., Tournier, M., ... & Bégaud, B. (2014). Benzodiazepine use and risk of Alzheimer’s disease: case-control study. British Medical Journal, 349, g5205.

45.

Doghramji, K., Grewal, R., & Markov, D. (2009). Evaluation and management of insomnia in the psychiatric setting. Focus, 7(4), 441-454.

46.

Dollman, W. B., LeBlanc, V. T., & Roughead, E. E. (2003). Managing insomnia in the elderly-what prevents us using non‐drug options?. Journal of Clinical Pharmacy and Therapeutics, 28(6), 485-491.

47.

Edinger, J. D., Bonnet, M. H., Bootzin, R. R., Doghramji, K., Dorsey, C. M., Espie, C. A., ... & Stepanski, E. J. (2004). Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep, 27(8), 1567-1596.

48.

Edinger, J. D., & Carney, C. E. (2015). Overcoming insomnia: A Cognitive-Behavioral Therapy Approach, Therapist Guide (2th ed.). Oxford: Oxford University Press.

49.

Edinger, J. D., Wohlgemuth, W. K., Radtke, R. A., Marsh, G. R., & Quillian, R. E. (2001). Does cognitive-behavioral insomnia therapy alter dysfunctional beliefs about sleep?. Sleep, 24(5), 591-599.

50.

Eidelman, P., Talbot, L., Ivers, H., Bélanger, L., Morin, C. M., & Harvey, A. G. (2016). Change in dysfunctional beliefs about sleep in behavior therapy, cognitive therapy, and cognitive-behavioral therapy for insomnia. Behavior Therapy, 47(1), 102-115.

51.

Espie, C. A. (2002). Insomnia: conceptual issues in the development, persistence, and treatment of sleep disorder in adults. Annual Review of Psychology, 53(1), 215-243.

52.

Espie, C. A., Barrie, L. M., & Forgan, G. S. (2012). Comparative investigation of the psychophysiologic and idiopathic insomnia disorder phenotypes: psychologic characteristics, patients’ perspectives, and implications for clinical management. Sleep, 35(3), 385-393.

53.

Espie, C. A., Inglis, S. J., Tessier, S., & Harvey, L. (2001). The clinical effectiveness of cognitive behaviour therapy for chronic insomnia: implementation and evaluation of a sleep clinic in general medical practice. Behaviour Research and Therapy, 39(1), 45-60.

54.

Espie, C. A., MacMahon, K. M., Kelly, H. L., Broomfield, N. M., Douglas, N. J., Engleman, H. M., ... & Wilson, P. (2007). Randomized clinical effectiveness trial of nurse-administered small-group cognitive behavior therapy for persistent insomnia in general practice. Sleep, 30(5), 574-584.

55.

Fang, S. C., Huang, C. J., Yang, T. T., & Tsai, P. S. (2008). Heart rate variability and daytime functioning in insomniacs and normal sleepers: preliminary results. Journal of Psychosomatic Research, 65(1), 23-30.

56.

Feige, B., Baglioni, C., Spiegelhalder, K., Hirscher, V., Nissen, C., & Riemann, D. (2013). The microstructure of sleep in primary insomnia: an overview and extension. International Journal of Psychophysiology, 89(2), 171-180.

57.

First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. (1996). Structured clinical interview for DSM-Ⅳ axis Ⅰ disorders, Clinician version (SCID-CV). Washington, DC: American Psychiatric Press.

58.

Fornal-Pawłowska, M., & Szelenberger, W. (2013). Cognitive behavioral therapy for chronic insomnia. Psychiatr Polska, 47(2), 269-279.

59.

Friedman, L., Benson, K., Noda, A., Zarcone, V., Wicks, D. A., O’Connell, K., ... & Yesavage, J. A. (2000). An actigraphic comparison of sleep restriction and sleep hygiene treatments for insomnia in older adults. Journal of Geriatric Psychiatry and Neurology, 13(1), 17-27.

60.

Fuller, J. M., Wong, K. K., Hoyos, C., Krass, I., & Saini, B. (2016). Dispensing good sleep health behaviours not pills-a cluster randomized controlled trial to test the feasibility and efficacy of pharmacist‐provided brief behavioural treatment for insomnia. Journal of Sleep Research, 25(1), 104-115.

61.

Guastella, A. J., & Moulds, M. L. (2007). The impact of rumination on sleep quality following a stressful life event. Personality and Individual Differences, 42(6), 1151-1162.

62.

Hammer, B. U., Colbert, A. P., Brown, K. A., & Ilioi, E. C. (2011). Neurofeedback for insomnia: A pilot study of Z-score SMR and individualized protocols. Applied Psychophysiology and Biofeedback, 36(4), 251-264.

63.

Harvey, A. G. (2002). A cognitive model of insomnia. Behaviour Research and Therapy, 40(8), 869-893.

64.

Harvey, A. G., Tang, N. K., & Browning, L. (2005). Cognitive approaches to insomnia. Clinical Psychology Review, 25(5), 593-611.

65.

Hatch, B. (2017). Sleep Spindles Predict Response to Cognitive Behavioral Therapy for Chronic Insomnia (Doctoral dissertation, Concordia University).

66.

Herrmann, C. S., & Demiralp, T. (2005). Human EEG gamma oscillations in neuropsychiatric disorders. Clinical Neurophysiology, 116(12), 2719-2733.

67.

Hoedlmoser, K., Dang Vu, T. T., Desseilles, M., & Schabus, M. (2011). Non pharmacological alternatives for the treatment of insomnia- Instrumental EEG condition ing, a new alternative. Melatonin, Sleep and Insomnia, 69.

68.

Horne, J. A., & Östberg, O. (1976). A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. International Journal of Chronobiology.

69.

Israel, B., Buysse, D. J., Krafty, R. T., Begley, A., Miewald, J., &Hall, M. (2012). Short-term stability of sleep and heart rate variability in good sleepers and patients with insomnia: for some measures, one night is enough. Sleep, 35(9), 1285-1291.

70.

Jarrin, D. C., Chen, I. Y., Ivers, H., Lamy, M., Vallières, A., & Morin, C. M. (2016). Nocturnal heart rate variability in patients treated with cognitive-behavioral therapy for insomnia. Health Psychology, 35(6), 638.

71.

Johns, M. W. (1991). A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep, 14(6), 540-545.

72.

Killgore, W. D., Schwab, Z. J., Kipman, M., DelDonno, S. R., &Weber, M. (2013). Insomnia-related complaints correlate with functional connectivity between sensory-motor regions. Neuroreport, 24(5), 233-240.

73.

Kripke, D. F., Langer, R. D., & Kline, L. E. (2012). Hypnotics’ association with mortality or cancer: a matched cohort study. BMJ open, 2(1), e000850.

74.

Krystal, A. D. (2008). Non-REM sleep EEG spectral analysis in insomnia. Psychiatric Annals, 38(9), 615.

75.

Krystal, A. D. (2009). A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for US clinical practice. Sleep Medicine Reviews, 13(4), 265-274.

76.

Krystal, A. D., Benca, R. M., & Kilduff, T. S. (2013). Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system. The Journal of Clinical Psychiatry, 74(suppl 1), 3-20.

77.

Krystal, A. D., & Edinger, J. D. (2008). Measuring sleep quality. Sleep Medicine, 9, S10-S17.

78.

Krystal, A. D., & Edinger, J. D. (2010). Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia. Sleep, 33(5), 669-677.

79.

Kuhn, E., Weiss, B. J., Taylor, K. L., Hoffman, J. E., Ramsey, K. M., Manber, R., ... &Trockel, M. (2016). CBT-I coach: a description and clinician perceptions of a mobile app for cognitive behavioral therapy for insomnia. Journal of Clinical Sleep Medicine, 12(4), 597.

80.

Kyle, S. D., Espie, C. A., & Morgan, K. (2010). “… Not just a minor thing, it is something major, which stops you from functioning daily”: quality of life and daytime functioning in insomnia. Behavioral Sleep Medicine, 8(3), 123-140.

81.

Kyle, S. D., Morgan, K., Spiegelhalder, K., & Espie, C. A. (2011). No pain, no gain: an exploratory within-subjects mixed-methods evaluation of the patient experience of sleep restriction therapy (SRT) for insomnia. Sleep Medicine, 12(8), 735-747.

82.

Levenson, J. C., Kay, D. B., & Buysse, D. J. (2015). The pathophysiology of insomnia. Chest, 147(4), 1179-1192.

83.

Lichstein, K. L., & Riedel, B. W. (1994). Behavioral assessment and treatment of insomnia: a review with an emphasis on clinical application. Behavior Therapy, 25(4), 659-688.

84.

Mai, E., & Buysse, D. J. (2008). Insomnia: prevalence, impact, pathogenesis, differential diagnosis, and evaluation. Sleep Medicine Clinics, 3(2), 167-174.

85.

Malik, M. (1996). Heart rate variability: Standards of measurement, physiological interpretation, and clinical use: Task force of the European Society of Cariology and the North American Society for Pacing and Electrophysiology. Annals of Noninvasive Electrocardiology, 1(2), 151-181.

86.

Mallon, L., Broman, J. E., & Hetta, J. (2009). Is usage of hypnotics associated with mortality?. Sleep Medicine, 10(3), 279-286.

87.

Merica, H., Blois, R., & Gaillard, J. M. (1998). Spectral characteristics of sleep EEG in chronic insomnia. European Journal of Neuroscience, 10(5), 1826-1834.

88.

Mitchell, M. D., Gehrman, P., Perlis, M., & Umscheid, C. A. (2012). Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review. BMC Family Practice, 13(1), 40.

89.

Moldofsky, H., Scarisbrick, P., England, R., & Smythe, H. (1975). Musculoskeletal symptoms and non-REM sleep disturbance in patients with “fibrositis syndrome” and healthy subjects. Psychosomatic Medicine.

90.

Morin, C. M. (1993). Insomnia: Psychological assessment and management. New York, NY: Guilford press.

91.

Morin, C. M. (2004). Cognitive-behavioral approaches to the treatment of insomnia. Journal of Clinical Psychiatry, 65(Suppl 16), 33-40.

92.

Morin, C. M., Bélanger, L., LeBlanc, M., Ivers, H., Savard, J., Espie, C. A., ... &Grégoire, J. P. (2009). The natural history of insomnia: a population-based 3-year longitudinal study. Archives of Internal Medicine, 169(5), 447-453.

93.

Morin, C. M., & Benca, R. (2012). Chronic insomnia. The Lancet, 379(9821), 1129-1141.

94.

Morin, C. M., Blais, F., & Savard, J. (2002). Are changes in beliefs and attitudes about sleep related to sleep improvements in the treatment of insomnia?. Behaviour Research and Therapy, 40(7), 741-752.

95.

Morin, C. M., Colecchi, C., Stone, J., Sood, R., & Brink, D. (1999). Behavioral and pharmacological therapies for late-life insomnia: a randomized controlled trial. Journal of the American Medical Association, 281(11), 991-999.

96.

Morin, C. M., & Espie, C. A. (2003). Insomnia: A clinician’s guide to assessment and treatment. New York, NY: Springer US

97.

Morin, C. M., Vallières, A., & Ivers, H. (2007). Dysfunctional beliefs and attitudes about sleep (DBAS): validation of a brief version (DBAS-16). Sleep, 30(11), 1547-1554.

98.

National Institutes of Health. (2005). NIH state-of-the-science conference statement on manifestations and management of chronic insomnia in adults. NIH Consens Sci Statements, 22, 1-30.

99.

Neubauer, D. N., Pandi-Perumal, S. R., Spence, D. W., Buttoo, K., & Monti, J. M. (2018). Pharmacotherapy of Insomnia. Journal of Central Nervous System Disease, 10, 1-7.

100.

Nicassio, P. M., Mendlowitz, D. R., Fussell, J. J., & Petras, L. (1985). The phenomenology of the pre-sleep state: the development of the pre-sleep arousal scale. Behaviour Research and Therapy, 23(3), 263-271.

101.

Niemcewicz, S., Szelenberger, W., Skalski, M., Androsiuk, W., Piotrowski, T., Myszka, D. M., & Moskwa, M. (2001). Psychophysiological correlates of primary insomnia. Psychiatria Polska, 35(4), 583-591.

102.

Nofzinger, E. A., Buysse, D. J., Germain, A., Price, J. C., Miewald, J. M., & Kupfer, D. J. (2004). Functional neuroimaging evidence for hyperarousal in insomnia. American Journal of Psychiatry, 161(11), 2126-2128.

103.

Oh, D. Y., Park, S. M., & Choi, S. W. (2020). Daytime Neurophysiological Hyperarousal in Chronic Insomnia: A Study of qEEG. Journal of Clinical Medicine, 9(11), 3425.

104.

Olfson, M., King, M., & Schoenbaum, M. (2014). Benzodiazepine use in the United States. JAMA Psychiatry, 72(2), 136-142.

105.

Okajima, I., Komada, Y., & Inoue, Y. (2011). A meta-analysis on the treatment effectiveness of cognitive behavioral therapy for primary insomnia. Sleep and Biological Rhythms, 9(1), 24-34.

106.

Omvik, S., Pallesen, S., Bjorvatn, B., Sivertsen, B., Havik, O. E., & Nordhus, I. H. (2010). Patient characteristics and predictors of sleep medication use. International Clinical Psychopharmacology, 25(2), 91-100.

107.

Ong, J., & Suh, S. (2012). Utilizing cognitive- behavioral therapy for insomnia to facilitate discontinuation of sleep medication in chronic insomnia patients. Sleep Medicine Research, 3(1), 1-6.

108.

Parazzini, M., Ravazzani, P., Tognola, G., Thuróczy, G., Molnar, F. B., Sacchettini, A., ... & Mainardi, L. T. (2007). Electromagnetic fields produced by GSM cellular phones and heart rate variability. Bioelectromagnetics, 28(2), 122-129.

109.

Park, K. M., Kim, T. H., Kim, W. J., An, S. K., Namkoong, K., & Lee, E. (2018). Cognitive behavioral therapy for insomnia reduces hypnotic prescriptions. Psychiatry Investigation, 15(5), 499.

110.

Perlis, M. L., Giles, D. E., Mendelson, W. B., Bootzin, R. R., & Wyatt, J. K. (1997). Psychophysiological insomnia: the behavioural model and a neurocognitive perspective. Journal of Sleep research, 6(3), 179-188.

111.

Perlis, M., Jungquist, C., Smith, M. T., & Posner, D. (2006). The cognitive behavioral treatment of insomnia: A Sesstion-by-Session Guide. New York, NY: SpringerVerlag New York.

112.

Perlis, M. L., Merica, H., Smith, M. T., &Giles, D. E. (2001). Beta EEG activity and insomnia. Sleep medicine reviews, 5(5), 365-376.

113.

Pérusse, A. D., Turcotte, I., St-Jean, G., Ellis, J., Hudon, C., &Bastien, C. H. (2013). Types of primary insomnia: is hyperarousal also present during napping?. Journal of clinical sleep medicine, 9(12), 1273-1280.

114.

Pumprla, J., Howorka, K., Howorka, N., Perneczky, E., & Rakovac, I. (2009). Economic impact of modular outpatient diabetes education programme. Wiener Klinische Wochenschrift, 121, S12-13.

115.

Qaseem, A., Kansagara, D., Forciea, M. A., Cooke, M., & Denberg, T. D. (2016). Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of Physicians. Annals of Internal Medicine, 165(2), 125-133.

116.

Ree, M. J., & Harvey, A. G. (2004). Investigating safety behaviours in insomnia: the development of the sleep-related behaviours questionnaire (SRBQ). Behaviour Change, 21(1), 26-36.

117.

Riemann, D., Baglioni, C., Bassetti, C., Bjorvatn, B., Dolenc Groselj, L., Ellis, J. G., ... & Hertenstein, E. (2017). European guideline for the diagnosis and treatment of insomnia. Journal of Sleep Research, 26(6), 675-700.

118.

Riemann, D., Nissen, C., Palagini, L., Otte, A., Perlis, M. L., & Spiegelhalder, K. (2015). The neurobiology, investigation, and treatment of chronic insomnia. The Lancet Neurology, 14(5), 547-558.

119.

Riemann, D., Spiegelhalder, K., Espie, C., Pollmächer, T., Léger, D., Bassetti, C., & Van Someren, E. (2011). Chronic insomnia: clinical and research challenges-an agenda. Pharmacopsychiatry, 44(01), 1-14.

120.

Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010). The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Medicine Reviews, 14(1), 19-31.

121.

Riemann, D., Spiegelhalder, K., Nissen, C., Hirscher, V., Baglioni, C., & Feige, B. (2012). REM sleep instability-a new pathway for insomnia?. Pharmacopsychiatry, 45(05), 167-176.

122.

Roehrs, T., Gumenyuk, V., Drake, C., & Roth, T. (2014). Physiological correlates of insomnia. Swizerland: Springer, Cham.

123.

Rosa, R. R., & Bonnet, M. H. (2000). Reported chronic insomnia is independent of poor sleep as measured by electroencephalography. Psychosomatic Medicine, 62(4), 474-482.

124.

Sateia, M. J., Doghramji, K., Hauri, P. J., & Morin, C. M. (2000). Evaluation of chronic insomnia. An American Academy of Sleep Medicine review. Sleep, 23(2), 243-308.

125.

Sato, M., Yamadera, W., Matsushima, M., Itoh, H., & Nakayama, K. (2010). Clinical efficacy of individual cognitive behavior therapy for psychophysiological insomnia in 20 outpatients. Psychiatry and Clinical Meurosciences, 64(2), 187- 195.

126.

Schutte-Rodin, S., Broch, L., Buysse, D., Dorsey, C., & Sateia, M. (2008). Clinical guideline for the evaluation and management of chronic insomnia in adults. Journal of Clinical Sleep Medicine, 4(5), 487.

127.

Shekleton, J. A., Rogers, N. L., & Rajaratnam, S. M. (2010). Searching for the daytime impairments of primary insomnia. Sleep Medicine Reviews, 14(1), 47-60.

128.

Silva-Costa, A., Griep, R. H., & Rotenberg, L. (2015). Associations of a short sleep duration, insufficient sleep, and insomnia with self-rated health among nurses. PLoS One, 10(5), e0126844.

129.

Sivertsen, B., Overland, S., Neckelmann, D., Glozier, N., Krokstad, S., Pallesen, S., ... & Mykletun, A. (2006). The long-term effect of insomnia on work disability: the HUNT-2 historical cohort study. American Journal of Epidemiology, 163(11), 1018-1024.

130.

Sohn, S. I., Kim, D. H., Lee, M. Y., & Cho, Y. W. (2012). The reliability and validity of the Korean version of the Pittsburgh Sleep Quality Index. Sleep and Breathing, 16(3), 803-812.

131.

Spiegelhalder, K., Regen, W., Feige, B., Holz, J., Piosczyk, H., Baglioni, C., ... & Nissen, C. (2012). Increased EEG sigma and beta power during NREM sleep in primary insomnia. Biological Psychology, 91(3), 329-333.

132.

Spielman, A. J., Saskin, P., & Thorpy, M. J. (1987). Treatment of chronic insomnia by restriction of time in bed. Sleep, 10(1), 45-56.

133.

Taylor, H. L., Rybarczyk, B. D., Nay, W., & Leszczyszyn, D. (2015). Effectiveness of a CBT intervention for persistent insomnia and hypnotic dependency in an outpatient psychiatry clinic. Journal of Clinical Psychology, 71(7), 666-683.

134.

Taylor, K., Bilan, N., Tsytsyna, N., & Mandel, E. D. (2017). A nonpharmacologic approach to managing insomnia in primary care. Journal of the American Academy of PAs, 30(11), 10-15.

135.

Van Houdenhove, L., Buyse, B., Gabriëls, L., & Van den Bergh, O. (2011). Treating primary insomnia: clinical effectiveness and predictors of outcomes on sleep, daytime function and health-related quality of life. Journal of Clinical Psychology in Medical Settings, 18(3), 312-321.

136.

van Straten, A., van der Zweerde, T., Kleiboer, A., Cuijpers, P., Morin, C. M., & Lancee, J. (2018). Cognitive and behavioral therapies in the treatment of insomnia: a meta-analysis. Sleep Medicine Reviews, 38(2), 3-16.

137.

Varkevisser, M., Van Dongen, H. P., & Kerkhof, G. A. (2005). Physiologic indexes in chronic insomnia during a constant routine: evidence for general hyperarousal?. Sleep, 28(12), 1588- 1596.

138.

Williams, J., Roth, A., Vatthauer, K., & McCrae, C. S. (2013). Cognitive behavioral treatment of insomnia. Chest, 143(2), 554-565.

139.

Wilson, S., Anderson, K., Baldwin, D., Dijk, D. J., Espie, A., Espie, C., ... & Sharpley, A. (2019). British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update. Journal of Psychopharmacology, 33(8), 923-947.

140.

Wilson, S. J., Nutt, D. J., Alford, C., Argyropoulos, S. V., Baldwin, D. S., Bateson, A. N., ... & Gringras, P. (2010). British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. Journal of Psychopharmacology, 24(11), 1577-1601.

141.

Winkelmayer, W. C., Mehta, J., & Wang, P. S. (2007). Benzodiazepine use and mortality of incident dialysis patients in the United States. Kidney International, 72(11), 1388-1393.

142.

Wołyńczyk-Gmaj, D., & Szelenberger, W. (2011). Waking EEG in primary insomnia. Acta Neurobiologiae Experimentalis, 71(3), 387-392.

143.

Wu, R., Bao, J., Zhang, C., Deng, J., & Long, C. (2006). Comparison of sleep condition and sleep-related psychological activity after cognitive-behavior and pharmacological therapy for chronic insomnia. Psychotherapy and Psychosomatics, 75(4), 220-228.

144.

Wu, Y. M., Pietrone, R., Cashmere, J. D., Begley, A., Miewald, J. M., Germain, A., & Buysse, D. J. (2013). EEG power during waking and NREM sleep in primary insomnia. Journal of Clinical Sleep Medicine, 9(10), 1031-1037.

145.

Youngstedt, S. D., & Kripke, D. F. (2004). Long sleep and mortality: rationale for sleep restriction. Sleep Medicine Reviews, 8(3), 159-174.

logo