- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effect of Gastrodia elata BL water extract on human cerebral blood flow？sing transcranial Doppler
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.1, pp.115-122
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(2005). Effect of Gastrodia elata BL water extract on human cerebral blood flow？sing transcranial Doppler. Journal of Korean Medicine, 26(1), 115-122.
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Abstract
Backgrounds and objectives: Gastrodiae Rhizoma(GR), the rhizoma of Gastrodia elata BL., is one of the popular drugs to treat headache, dizziness, blackout, numbness of limbs, hemiplegia, facial paralysis, dysphrasia, and infantile convulsions. It has been reported that it represents antihypertensive effect and lowering cerebrovascular resistance with animal experiments. However, there has been no data about these effects with human subjects. In this study, the author examined the effect of Gastrodiae water extrats on blood pressure and cerebrovascular reactivity in human subjects. Methods: We selected 16 normal volunteers, who were divided into 2 groups; Gastrodiae extract administration group, placebo(creamy powder) group. Using transcranial Doppler ultrasound, We monitored changes of mean flow velocity and breath-holding induced CO2 reactivity of middle cerebral artery in both groups. Mean blood pressure, heart rate and PETCO2 were measured using Compact Anesthesia Monitor. In both groups, all evaluation was performed during basal condition, and repeated at 30, 60, and 90 min after administration. Results: Gastrodiae extract decreased CO2 reactivity after administration, reaching the lowest level at 90 minute (-29.1% vs basal level), which showed significant difference compared with placebo group(p = 0.004). In placebo group, the pulse rates tended to decrease over time(at 90 minute, -5.2% vs basal level) while in gastrodiae group the values showed nearly no change, which showed significant difference between both groups(p = 0.036). However, the changes of mean blood pressure and mean flow velocity did not show significant difference between both groups. Conclusions: This study demonstrated that Gastrodiae extract significantly decreased breath-holding induced CO2 reactivity. This result suggest that the clinical effect of Gastrodiae extract might be caused by increasing cerebral blood flow via dilation of cerebral resistant vessels instead of antihypertensive effect.
- keywords
- Gastrodiae Rhizomatranscranial Doppler ultrasoundcerebral blood flowcerebrovascular reactivitymean blood pressurepulse rate, Gastrodiae Rhizomatranscranial Doppler ultrasoundcerebral blood flowcerebrovascular reactivitymean blood pressurepulse rate
Reference
1
(1986) 원색 임상본초학, 남산당
2
(1994) 중약현대연구여임상응용, 학원출판사
3
(1997) 천마의 항고혈압작용에 관한 연구,
4
(1995) 천마엑기스가 Spontaneously Hypertensive Rat에서 혈압 및 혈장 Catecholamine 함량의 변화에 미치는 영향,
5
(1999) 천마의 4 Vessel Occlusion으로 유발한 흰쥐 전뇌허혈에 대한 신경보호 효과,
6
(1999) 파킨슨병에서 도파민성 신경세포손상에 대한 천마의 방어효과에 관한 연구,
7
(2002) 고콜레스테롤 식이 랫드에서 천마혼합액의 혈액개선 효과,
8
(1995) 정상인에서 도플러 초음파술을 이용하여 측정한 니트로글리세린 투여후 두개내 혈류속도의 변화,
9
(1994) Differential effect of three cyclooxygenase inhibitors on human cerebral blood flow velocity and carbon dioxide reactivity,
10
(1989) Effect of nitroglycerin on cerebral circulation measured by transcranial Doppler and SPECT,Stroke,
11
(1996) Effect of smoking on cerebrovascular reactivity,Journal of cerebral blood flow and metabolism,
12
(1999) 우황청심원이 정상인의 뇌혈류 및 혈압에 미치는 영향,
13
(2000) 뇌경색 환자의 뇌혈류에 대하여 건측 및 환측 침치료가 미치는 영향에 관한 비교 연구,
14
(1997) 뇌경색환자의 혈압ㆍ맥박 및 뇌혈류에 대하여 수구ㆍ승장혈 전침자극이 미치는 영향,
15
(1996) Cerebral vasomotor reactivity:functional tests,
16
(1992) Use of breath holding for evaluating cerebrovascular reserve capacity,
17
(1992) Estimation of cerebrovascular reactivity using transcranial Dopplers including the use of breath-holding as the vasodilatory stimulus,
18
(2001) Pharmacology and Applications of Chinese Materia Medica Vol,
19
(1997) Metabolism of Saikosaponin c and Naringin by Human Intestinal Bacteria,
20
(1996) Metabolism of Glycyrrhizin and Baicalin by Human Intestinal Bacteria,
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