- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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천마추출물이 정상인의 뇌혈류에 미치는 영향
Effect of Gastrodia elata BL water extract on human cerebral blood flow？sing transcranial Doppler
대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.1, pp.115-122
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
(경희대학교)
문상관,
김영석,
박성욱,
정우상,
고창남,
조기호,
&
배형섭.
(2005). 천마추출물이 정상인의 뇌혈류에 미치는 영향. 대한한의학회지, 26(1), 115-122.
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Abstract
Backgrounds and objectives: Gastrodiae Rhizoma(GR), the rhizoma of Gastrodia elata BL., is one of the popular drugs to treat headache, dizziness, blackout, numbness of limbs, hemiplegia, facial paralysis, dysphrasia, and infantile convulsions. It has been reported that it represents antihypertensive effect and lowering cerebrovascular resistance with animal experiments. However, there has been no data about these effects with human subjects. In this study, the author examined the effect of Gastrodiae water extrats on blood pressure and cerebrovascular reactivity in human subjects. Methods: We selected 16 normal volunteers, who were divided into 2 groups; Gastrodiae extract administration group, placebo(creamy powder) group. Using transcranial Doppler ultrasound, We monitored changes of mean flow velocity and breath-holding induced CO2 reactivity of middle cerebral artery in both groups. Mean blood pressure, heart rate and PETCO2 were measured using Compact Anesthesia Monitor. In both groups, all evaluation was performed during basal condition, and repeated at 30, 60, and 90 min after administration. Results: Gastrodiae extract decreased CO2 reactivity after administration, reaching the lowest level at 90 minute (-29.1% vs basal level), which showed significant difference compared with placebo group(p = 0.004). In placebo group, the pulse rates tended to decrease over time(at 90 minute, -5.2% vs basal level) while in gastrodiae group the values showed nearly no change, which showed significant difference between both groups(p = 0.036). However, the changes of mean blood pressure and mean flow velocity did not show significant difference between both groups. Conclusions: This study demonstrated that Gastrodiae extract significantly decreased breath-holding induced CO2 reactivity. This result suggest that the clinical effect of Gastrodiae extract might be caused by increasing cerebral blood flow via dilation of cerebral resistant vessels instead of antihypertensive effect.
- keywords
- Gastrodiae Rhizomatranscranial Doppler ultrasoundcerebral blood flowcerebrovascular reactivitymean blood pressurepulse rate, Gastrodiae Rhizomatranscranial Doppler ultrasoundcerebral blood flowcerebrovascular reactivitymean blood pressurepulse rate
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