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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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紫草가 항알러지 염증반응에 미치는 영향

Anti-allergic and Anti-inflammatory Effects of Jacho (Lithospermum Erythrorhizon)

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.110-123
권미화 (경희대학교 한의과대학 소아과교실)
이진용 (경희대학교)
김덕곤 (경희대학교)
권미화, 이진용, & 김덕곤. (2005). 紫草가 항알러지 염증반응에 미치는 영향. 대한한의학회지, 26(3), 110-123.
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Abstract

Objectives : This study was performed to examine the anti-allergic and anti-inflammatory effects of Jacho (Lithospermum erythrorhizon). Methods : Macrophage 264.7 cells were pretreated for 1 hour with Jacho. After pretreatment, macrophages were incubated with lipopolysaccharide (LPS) 100ng/ml for 12 h (TNF-α, IL-6) or 24 h (IL-1β, IL-10) and media collected and TNF-α, IL-6, IL-1β, and IL-10 concentrations in supernatants were each measured by enzyme-linked immunosorbent assay. Concentrations of Jacho used were 50, 100, 250, 500, and 1000 ㎍/㎖, and hydrocortisones used were 10-8, 10-7, 10-6, 10-5, and 10-4 M. Results : Jacho showed inhibitory effect on TNF-αby LPS-stimulated macrophage 264.7. The inhibitory effect was most significant in 250 ㎍/㎖, and was not in a dose-dependent manner as in the hydrocortisone group . Jacho also showed inhibitory effect on IL-6 by LPS-stimulated macrophage 264.7. The inhibitory effect was most significant in 1000 ㎍/㎖, and increased in a roughly dose-dependent manner. Jacho and hydrocortisone showed contrary effect on IL-1β. Jacho obviously increased the expression of IL-1β‚ in all five concentrations, and at the lowest concentration (50 ㎍/㎖) the level of IL-1β‚ was highest. On the other hand, hydrocortisone was observed to have inhibitory effect on IL-1β‚ in all five concentrations. IL-10 was obviously inhibited by Jacho and hydrocortisone respectively in a roughly dose-dependent manner. Conclusions : By the findings of this experiment, Jacho was observed to have anti-allergic and anti-inflammatory effects through inhibiting pro-inflammatory cytokine TNF-αand IL-6, and might be one of the effective therapeutic regimens for allergic diseases.

keywords
Jacho, Lithospermum erythrorhizon, allergic disease, atopic dermatitis, inflammatory cytokine, TNF-α, IL-6, IL-1β‚ IL-10


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