- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Anti-neuronal Injury Effect of Evodiae FructusWater Extract in Sodium Cyanide-induced SK-N-SH Cell Lines
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.135-145
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(2005). Anti-neuronal Injury Effect of Evodiae FructusWater Extract in Sodium Cyanide-induced SK-N-SH Cell Lines. Journal of Korean Medicine, 26(3), 135-145.
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Abstract
Objectives : This study investigated effects of Evodiae fructus water extract (EVOR) on apoptotic cell death induced by NaCN in SK-N-SH neuroblastoma cell lines. NaCN stimulates glutamate release which can activate glutamate receptors to initiate excitotoxic processes. This study examines the role of EVOR in mediating NaCN-induced cytotoxicity. Methods & Results : Cytotoxicity was assessed by measuring lactate dehydrogenase (LDH) in the culture media. NaCN (0.1mM) produced cytotoxicity following 12hrs of incubation. NaCN-induced cytotoxicity was partially blocked by EVOR. The treatment of EVOR in simultaneous exposure of cultures to NaCN provided complete protection against cytotoxicity. NaCN-induced cytotoxicity was found to inhibit DNA fragmentation, repaired by cell cycle and simultaneous exposure to NaCN, regenerated with neurite outgrowth by EVOR. These results indicate that damage by NaCN in neuronal cell cultures was repaired by EVOR, whereas NaCN-induced cytotoxicity is blocked primarily by activation of anti-apoptosis. Conclusions : These results suggest that EVOR may be beneficial for the treatment of dementia and other degenerative problems of the central nervous system.
- keywords
- Sodium cyanide, Evodiae fructus, anti-neuronal injury
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