- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effects of Pyungjintang on Indomethacin-induced Gastric Mucosal Lesions in Mice
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.215-227
&
(2005). Effects of Pyungjintang on Indomethacin-induced Gastric Mucosal Lesions in Mice. Journal of Korean Medicine, 26(3), 215-227.
- Downloaded
- Viewed
Abstract
Objectives : This study was carried out to investigate the effects of Pyungjintang on indomethacin-induced gastric mucosal lesions of mice. Methods : Experimental mice were classified into not-treated group (NOR group), gastro-inflammation elicitated group (CON group), misoprostol-administered group after gastro-inflammation elicitation (MA group), and Pyungjintangadministered group after gastro-inflammation elicitation (PA group). This study examined the morphological change, distribution of mast cells, mucus surface cells, neutral mucus secreting cells, acid mucus secreting cells, PNA reaction, angiogenesis (MIP-2), COX-1, Hsp70, NF-κB p50, COX-2 IL-12B, ICAM-1, BrdU and apoptotic cells of gastric mucosa. Results : 1. The scars of diapedesis, dilatation of right gastric artery and the hemorrhagic erosions of gastric mucosa were reduced in the MA and PA groups. 2. Gastric perforation was observed in the gastro-inflammation elicitated group, but not in the MA and PA groups. 3. The COX-1 positive cells, cell proliferation of gastric mucosa, neutral mucus secreting cells, acid mucus secreting cells and PNA positive reaction of surface mucus cells were increased in the MA and PA groups. 4. The distribution of apoptotic cells, mast cells, MIP-2, Hsp70, NF-κB p50, COX-2, IL-12B and ICAM-1 were decreased in the MA and PA groups. Conclusions : Pyungjintang had excellent effects on indomethacin-induced gastric mucosal lesions in mice.
- keywords
- Pyungjintang (pingchentang), indomethacin, misoprostol, gastric mucosal lesions
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Pharmacological action of Radix Scutellariae on nicotine-induced locomotor activity and c-Fos expression in the rats.
- The Effect of Herbal-acupuncture using Ursi Fel into Zusanli(ST36) to Recover Function of Stratum Corneum on Mice Model after Atopic Dermatitis Elicitation.
- Neuroprotective and memory enhancing effects of Pinelliae rhizoma extract
- Quality of Life in Patients with Skin Disease
- The Effcects of Psoraleae fructus Extract on Melanin Synthesis of B16 Melanoma Cells
- Effect of Choksamni(足三里, ST36) Moxibustion on Blood Pressure Elevation in Hypertensive Patients: A Randomized Controlled Trial.
- The Clinical Study on the Effect of Jeondo-san(Diandao-san) on Acnes.
- A Study on the Clinical Characteristics of 4-Constitution Groups in 8-Constitution Medicine
- Effective Antibacterial Activity of Salvia Miltiorrhiza against Streptococcus Pneumoniae ATCC 33400
- Anti-allergic and Anti-inflammatory Effects of Jacho (Lithospermum Erythrorhizon)
- The Study about Stop-Smoking Program Contains Oriental Medical Treatments
- Anti-neuronal Injury Effect of Evodiae FructusWater Extract in Sodium Cyanide-induced SK-N-SH Cell Lines
- Effects of Polygoni Multiflori Radix on Cerebral Ischemia of Hyperlipidemic Rats.
- Effects of Hyeolbuchukyeo-tang on Stress
- Anti-inflammation, Anti-Development and Curative Effects of Oyaksunki sangamibang on the Collagen-Induced Arthritis in Rats
- The Effects of Jayun-tang on the Changes of Cerebral Flow
- Antioxidant Property of the Gagam-Hyungbang-Gihwang-tang Using Biochemical Markers of Carcinogenesis
- Effects of Pyungjintang on Indomethacin-induced Gastric Mucosal Lesions in Mice
- The Effect of Korean, Chinese and American Ginseng on Blood Pressure of Hypertensive Patients
- Activation of Spinal Serotonergic Receptor Contributes to Electroacupuncture Analgesia in Rat with Chronic Pain
- The Effects of Evodia Rutaecarpa and Ephedra Sinica on the Resting Metabolic Rate and Body Composition of Obese Women on a Low-Calorie Diet: A Double-blinded Randomized Controlled Clinical Trial
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.