- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effective Antibacterial Activity of Salvia Miltiorrhiza against Streptococcus Pneumoniae ATCC 33400
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.98-109
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(2005). Effective Antibacterial Activity of Salvia Miltiorrhiza against Streptococcus Pneumoniae ATCC 33400. Journal of Korean Medicine, 26(3), 98-109.
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Abstract
Objectives : This study was designed to identify the effects of Salvia Miltiorrhiza on antibacterial activity against Streptococcus pneumoniae ATCC 33400. Methods : The ethanol- and water-extracts of more than 80 oriental herbal medicines were investigated by the Kirby-Bauer method to determine their inhibitory effect on growth of S. pneumoniae ATCC 33400 in vitro. Of them, Salvia Miltiorrhiza was selected. Results : The ethanol-soluble extract of Salvia Miltiorrhiza showed relatively high antibacterial activity against S. pneumoniae ATCC 33400. However, the water-soluble extract of Salvia Miltiorrhiza showed no antibacterial activity. The ethanolic extract was further fractionated with organic solvents such as hexane, chloroform, and ethyl acetate in that order. Among the fraction tested, the chloroform fraction showed the highest antibacterial activity, when the ethanol-soluble extract of Salvia Miltiorrhiza minimal inhibitory concentration (MIC) was 25 ㎍/㎖. Conclusions : Further study should be carried out to identity of the cell growth inhibition effects of S. pneumoniae ATCC 33400.
- keywords
- Pneumonia, Streptococcus pneumoniae, Salvia Miltiorrhiza, antibacterial activity, minimal inhibitory concentration.
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