- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Anti-inflammation, Anti-Development and Curative Effects of Oyaksunki sangamibang on the Collagen-Induced Arthritis in Rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.176-187
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(2005). Anti-inflammation, Anti-Development and Curative Effects of Oyaksunki sangamibang on the Collagen-Induced Arthritis in Rats. Journal of Korean Medicine, 26(3), 176-187.
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Abstract
Objectives : This study was carried out to investigate the anti-inflammation, anti-development and curative effects of Oyaksunki-sangamibang (OSKM) on collagen-induced arthritis in Wistar rats and ICR mice. Materials & Methods : In experiment part II, the inhibitory effects of nitric oxide synthesis, pro-inflammatory cytokines, and cyclooxygenase were studied. In experiment part II, paw edema volume and thickness of ankle joint were measured at 0, 10, 15, and 20 days after immunization. The incidence and arthritis score were evaluated 14 days after immunization. At 15 days after immunization, serum TNF-αwas analyzed. In experiment part III paw edema volume and thickness of ankle joint were measured at 0, 10, and 15 days after treatment. At 15 days after treatment, serum TNF-αwas analyzed. Results : In experiment part I: 1. Nitric oxide synthesis and pro-inflammatory cytokines were inhibited significantly by OSKM extract. 2. Cyclooxygenase 2 (COX-2) was inhibited by OSKM extract. In experiment part II: Paw edema volume, thickness of ankle joint, and serum TNF-αlevel of the treated group were significantly decreased compared with the control group at 20 days after immunization. In experiment part III: Incidence of arthritis was 70 %. OSKM-treated group had no significant change on paw edema volume, thickness of ankle joint and serum TNF-αlevel. Conclusions : These results indicated that OSKM has anti-inflammation effects on the ICR mouse, and higher inhibitory effects on the onset but lower inhibitory effects on the progression of collagen-induced arthritis in rats.
- keywords
- Oyaksunki-sangamibang (OSKM), collagen-induced arthritis, anti-inflammation.
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