- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Activation of Spinal Serotonergic Receptor Contributes to Electroacupuncture Analgesia in Rat with Chronic Pain
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.239-248
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(2005). Activation of Spinal Serotonergic Receptor Contributes to Electroacupuncture Analgesia in Rat with Chronic Pain. Journal of Korean Medicine, 26(3), 239-248.
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Abstract
Objectives : Electroacupuncture (EA)-induced analgesia has been known to be mediated through the activation of opioid, noradrenergic and serotonergic receptors. However, little study on serotonergic mechanism has been performed in an animal model of chronic pain. The present study was designed to elucidate the type of serotonergic receptors responsible for EA analgesia in the chronic pain model. Methods : In rats with complete Freund’s adjuvant-induced inflammation and spinal nerve injury, spinal wide dynamic range (WDR) cell responses to graded electrical stimulation of afferent C fiber were recorded before and after spinal application of selective 5-hydroxytryptamine (5-HT) receptor antagonists. EA stimulation (2Hz, 0.5msec, 3mA) was applied to the contralateral Zusanli point for 30 min. Results : In both models of chronic pain, WDR cell responses were greatly inhibited after EA stimulation. EA-induced inhibition of WDR cell responses was significantly attenuated by spinal application of non-selective 5-HT receptor antagonist, dihydroergocristine. Of 5-HT receptor antagonists tested, 5-HT1A (WAY100635) and 5-HT2 (LY53857) receptor antagonists strongly reduced an ability of EA stimulation to inhibit WDR cell responses. However, 5-HT1B (GR55562) and 5-HT3 (LY278584) receptor antagonists also had weak but significant blocking action on EA-induced inhibitory effect on chronic pain. Conclusions : Dorsal horn cell responses, afferent C fiber stimulation, chronic pain, electroacupuncture, serotonergic receptors.
- keywords
- Dorsal horn cell responses, Afferent C fiber stimulation, Chronic pain, Electroacupuncture, Serotonergic receptors.
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