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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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血府逐瘀湯이 스트레스에 미치는 영향

Effects of Hyeolbuchukyeo-tang on Stress

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.162-175
최유경 (경원대학교)
박종형 (경원대학교)
전찬용 (경원대학교)
김동우 (경원대학교)
황귀서 (경원대학교)
최유경, 박종형, 전찬용, 김동우, & 황귀서. (2005). 血府逐瘀湯이 스트레스에 미치는 영향. 대한한의학회지, 26(3), 162-175.
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Abstract

Backgrounds : Two stress pathways, the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system, regulate immune system responses through release of corticosteroids, norepinephrine and epinephrine, respectively. These neuromediators act on immune cells via specific receptors on their surface to modulate the production of key regulatory cytokines. Objectives : To evaluate the preventive effects of oriental medicine Hyeolbuchukyeo-tang (HC) on stress. Methods : Mice were divided into three groups: normal group, control group under immobilization stress and HC group which received Hyeolbuchukyeo-tang (HC) under immobilization stress. Following sacrifice, their splenocytes were isolated and splenocyte surface markers were determined. The brains were removed and mRNA determined. In vivo, we separated RNA from cultured macrophages (RAW264.7). Results : In our study, immune functions were decreased in stress due mainly to changes of various neuromediators, cytokines and macrophage activities, and the treatment of HC increased those expressions. Conclusions : In summary, the present study documents the anti-stress effects of HC through stress-immune regulation.

keywords
Stress, immune, neuromediator, cytokine, macrophage, Hyeolbuchukyeo-tang


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