Antioxidant Property of the Gagam-Hyungbang-Gihwang-tang Using Biochemical Markers of Carcinogenesis

한진수; 박성식

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P-ISSN 1010-0695
E-ISSN 2288-3339

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26권 3호

Antioxidant Property of the Gagam-Hyungbang-Gihwang-tang Using Biochemical Markers of Carcinogenesis

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339

2005, v.26 no.3, pp.204-214

한진수 (동국대학교 한의과대학 사상체질과)
박성식 (동국대학교)

한진수, & 박성식. (2005). 加減荊防地黃湯熱水추출물이 抗酸化작용에 미치는 影響. 대한한의학회지, 26(3), 204-214.

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Abstract

Objectives : The verity extract of the Gagam-Hyungbang-Gihwang-tang (GHG) was assessed to determine the mechanisms of its antioxidant activity. Methods : The following effects were measured : GHG exhibited a concentration-treatment; scavenging α,α-diphenyl-β- picrylhydrazyl (DPPH) radical, linoleic acid oxidation in a thiocyanate assay system, and superoxide anion, hydroxyl radicalinduced DNA nicking. We investigated mRNA levels such as superoxide-dismutase. Results : The GHG extract showed dose-dependent free radical scavenging activity, including DPPH radicals, hydroxyl radicals, and superoxide anion, using different systems. The GHG was also found to be effective in protecting plasmid DNA against the strand breakage induced by hydroxyl radicals in Fenton’ s reaction mixture. Furthermore, SOD-1 mRNA expression levels increased in rat hepatoma H4IIE cells. Conclusions : We expect that GHG will be helpful to the development of antioxidant activity treatments.

keywords: Hyungbang-Gihwang-tang, antioxidant activity, DPPH, superoxide anion, superoxide dismutase-1

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加減荊防地黃湯熱水추출물이 抗酸化작용에 미치는 影響

Antioxidant Property of the Gagam-Hyungbang-Gihwang-tang Using Biochemical Markers of Carcinogenesis

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