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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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Indomethacin으로 유발된 생쥐의 위점막 손상에 대한 平陳湯의 효과

Effects of Pyungjintang on Indomethacin-induced Gastric Mucosal Lesions in Mice

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.215-227
박정한 (상지대학교 한의과대학 내과교실)
백태현 (상지대학교 한의과대학 내과교실)
박정한, & 백태현. (2005). Indomethacin으로 유발된 생쥐의 위점막 손상에 대한 平陳湯의 효과. 대한한의학회지, 26(3), 215-227.
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Abstract

Objectives : This study was carried out to investigate the effects of Pyungjintang on indomethacin-induced gastric mucosal lesions of mice. Methods : Experimental mice were classified into not-treated group (NOR group), gastro-inflammation elicitated group (CON group), misoprostol-administered group after gastro-inflammation elicitation (MA group), and Pyungjintangadministered group after gastro-inflammation elicitation (PA group). This study examined the morphological change, distribution of mast cells, mucus surface cells, neutral mucus secreting cells, acid mucus secreting cells, PNA reaction, angiogenesis (MIP-2), COX-1, Hsp70, NF-κB p50, COX-2 IL-12B, ICAM-1, BrdU and apoptotic cells of gastric mucosa. Results : 1. The scars of diapedesis, dilatation of right gastric artery and the hemorrhagic erosions of gastric mucosa were reduced in the MA and PA groups. 2. Gastric perforation was observed in the gastro-inflammation elicitated group, but not in the MA and PA groups. 3. The COX-1 positive cells, cell proliferation of gastric mucosa, neutral mucus secreting cells, acid mucus secreting cells and PNA positive reaction of surface mucus cells were increased in the MA and PA groups. 4. The distribution of apoptotic cells, mast cells, MIP-2, Hsp70, NF-κB p50, COX-2, IL-12B and ICAM-1 were decreased in the MA and PA groups. Conclusions : Pyungjintang had excellent effects on indomethacin-induced gastric mucosal lesions in mice.

keywords
Pyungjintang (pingchentang), indomethacin, misoprostol, gastric mucosal lesions


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