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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

補骨脂추출물이 B16 melanoma 세포주의 멜라닌 합성에 미치는 영향

The Effcects of Psoraleae fructus Extract on Melanin Synthesis of B16 Melanoma Cells

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.55-65
정재호 (상지대학교 한의과대학 안이비인후피부과학교실)
서형식 (부산대학교)
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Abstract

Objectives : This study was carried out for the development of medicine for vitiligo treatment and focused on the effect of Psoraleae fructus extract on melanin synthesis of B16 melanoma cells. Methods : Activity of tyrosinase playing a vital role in the synthesis and quantity of melanin, which is the final product in cultured B16 melanoma cells, the effects of Psoraleae fructus extract were measured. Results : The results indicated that Psoraleae fructus extract increased both the amount of melanin and the activity of tyrosinase according to concentration, also supported by western blot analysis. Conclusions : The results suggest that Psoraleae fructus extract has an advantageous effect on the promotion of melanin synthesis and will contribute to the development of vitiligo treatment through further related studies.

keywords
Psoraleae fructus, melanogenesis, tyrosinase, vitiligo.


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