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  • E-ISSN 2288-3339

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Streptococcus Pneumoniae에 대한 丹蔘의 生育抑制效果

Effective Antibacterial Activity of Salvia Miltiorrhiza against Streptococcus Pneumoniae ATCC 33400

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.3, pp.98-109
박재훈 (동국대학교 분당한방병원)
정운석 (동국대학교)
이주일 (동국대학교)
서운교 (동국대학교)
박재훈, 정운석, 이주일, & 서운교. (2005). Streptococcus Pneumoniae에 대한 丹蔘의 生育抑制效果. 대한한의학회지, 26(3), 98-109.
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Abstract

Objectives : This study was designed to identify the effects of Salvia Miltiorrhiza on antibacterial activity against Streptococcus pneumoniae ATCC 33400. Methods : The ethanol- and water-extracts of more than 80 oriental herbal medicines were investigated by the Kirby-Bauer method to determine their inhibitory effect on growth of S. pneumoniae ATCC 33400 in vitro. Of them, Salvia Miltiorrhiza was selected. Results : The ethanol-soluble extract of Salvia Miltiorrhiza showed relatively high antibacterial activity against S. pneumoniae ATCC 33400. However, the water-soluble extract of Salvia Miltiorrhiza showed no antibacterial activity. The ethanolic extract was further fractionated with organic solvents such as hexane, chloroform, and ethyl acetate in that order. Among the fraction tested, the chloroform fraction showed the highest antibacterial activity, when the ethanol-soluble extract of Salvia Miltiorrhiza minimal inhibitory concentration (MIC) was 25 ㎍/㎖. Conclusions : Further study should be carried out to identity of the cell growth inhibition effects of S. pneumoniae ATCC 33400.

keywords
Pneumonia, Streptococcus pneumoniae, Salvia Miltiorrhiza, antibacterial activity, minimal inhibitory concentration.


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