In this paper, a study was conducted to find main factorsto Pima Indians Diabetes based on machine learning. Diabetes is a type of metabolic disease such as insufficient secretion of insulin or inability to function normally and is characterized by a high blood glucose concentration. According to a situation report from WHO(World Health Organization), Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar), which leads over time to serious damage to the heart, blood vessels, eyes, kidneys and nerves. And also about 422 million people worldwide have diabetes, the majority living in low-and middle-income countries, and 1.6 million deaths are directly attributed to diabetes each year. Both the number of cases and the prevalence of diabetes have been steadily increasing over the past few decades. Therefore, in this study, we used Support Vector Machine (SVM), Decision Tree, and correlation analysisto discover three important factorsthat predict Pima Indians diabetes with 70% accuracy. Applying the results suggested in this paper, doctors can quickly diagnose potential Pima Indians diabetics and prevent Pima Indians diabetes.