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Neuropsychological Differentiation betweenMild Alzheimer's Disease and Subcortical Vascular Dementia

Abstract

This study attempted not only to evaluate neuropsychological function and dysfunction of different types of dementia, but also to investigate the accuracy of neuropsychological tests in differentiation of each group. Two demented groups, mild Alzheimer's disease (AD) group and mild subcortical vascular dementia (SVD) group (all of whom had SVD due to small vessel disease), and normal aging control (NC) group participated in this study. Each group consisted of 24 participants and were matched on age, gender, and education level. Seoul Neuropsychological Screening Battery was administered to each participant. The findings were as follows. Demented groups (AD and SVD) performed significantly worse than NC group in most subtests of neuropsychological battery. Within the demented groups, AD group performed significantly worse than SVD group in Korean-Boston Naming Test (K-BNT), and they also showed more deficits than SVD group in recognition score of Seoul Verbal Learning Test (SVLT) and Rey Complex Figure Test (RCFT). SVD group performed significantly worse than AD group in most subtests measuring frontal functions, and they also showed more deficits than AD group in Digit span test. Discriminant analysis indicated that overall percentage of correct classification was 93.1%. SVLT recognition score highly correlated with Function 1 which discriminates demented groups from NC group. Function 2 discriminates between AD group and SVD group. K-BNT was the most effective discriminant for AD group, and phonemic fluency index of Word fluency test was the most effective discriminant for SVD group. Based on the results obtained, implications and limitations of this study were discussed.

keywords
dementia, Alzheimer's disease, vascular dementia, subcortical vascular dementia, neuropsychological function, neuropsychological evaluation, dementia, Alzheimer's disease, vascular dementia, subcortical vascular dementia, neuropsychological function, neuropsychological evaluation, 치매, 알쯔하이머형 치매, 혈관성 치매, 피질하 치매, 신경심리기능, 신경심리평가

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