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This study investigated the neuropsychological functioning of female college students with schizotypal and obsessive-compulsive traits. Based on scores from the Schizotypal Personality Questionnaire(SPQ), Maudsley Obsessive-Compulsive Inventory(MOCI), and the Padua Inventory(PI), schizotypal-trait(n=18), obsessive -compulsive trait(n=19) and normal control(n=22) groups were selected. For the measurement of neuropsychological functions, attention(Trail Making Test: TMT, d2, Stroop test), memory(Korean version of California Verbal Learning Test: K-CVLT, Rey-Osterrieth Complex Figure Test: RCFT), and executive(Wisconsin Card Sorting Test: WCST) tests were administered. The schizotypal-trait group demonstrated significantly prolonged response time on the word-reading task of the Stroop test and poorer concentration performance of the d2 test than both the obsessive-compulsive trait and control groups. In addition, the schizotypal-trait and obsessive-compulsive trait groups exhibited more total errors, perseverative responses and perseverative errors on the WCST. In other words, the schizotypal-trait group demonstrated deficits in attention, memory and executive function, whereas the obsessive-compulsive trait group showed deficits in executive function only. In addition, the obsessive-compulsive trait group exhibited significantly higher scores on SPQ than normal controls, while the schizotypal-trait group demonstrated higher scores on the MOCI and PI than normal controls. These neuropsychological and behavioral results indicate that both schizotypal-trait and obsessive-compulsive trait groups share common cognitive deficits, i.e., deficits in executive function, and symptoms.
권석만 (1995). 정신병리와 인지 I: 정서장애를 중심으로. 1995년도 한국심리학회 동계 연구 세미나 발표집: 심리학 연구의 통합적 탐색.
김정기, 강연욱 (1999). K-CVLT: 신경심리학적 기억검사 (성인용). 도서출판 특수교육.
문희옥, 양익홍, 이흥표, 김묘은, 함 웅 (1997). 한국판 분열형 성격척도의 타당화 예비연구. 신경정신의학, 36(2), 329-343.
민병배, 원호택 (1999). 한국판 Maudsley 강박행동질문지와 Padua 강박질문지의 신뢰도와 타당도. 한국심리학회지: 임상, 18(1), 163-182.
이영호, 송종용 (1991). BDI, SDS, MMPI-D 척도의 신뢰도 및 타당도에 대한 연구. 한국심리학회지: 임상, 10, 98-112.
이흥표, 양익홍 (1997). 분열형 성격과 비합리적 신념간의 관계. 한국심리학회지: 임상, 16(2), 161-171.
한오수, 안준호, 송선희, 조맹제, 김장규, 배재남, 조성진, 정범수, 서동우, 함봉진, 이동우, 박종익, 홍진표 (2000). 한국어판 구조화 임상면담도구 개발: 신뢰도 연구. 한국신경정신의학회, 39(2), 362-372 .
Abbruzzese, M., Bellodi, L., Ferri, S., and Scarone, S (1995). Frontal lobe dysfunction in schizophrenia and obsessive–compulsive disorder: a neuropsychological study. Brain and Cognition, 27, 202–212.
Bagary, M. S., Symms, M. R., Barker, G. J., Mutsatsa, S. H., Joyce, E. M., and Ron, M. A. (2003). Gray and white matter brain abnormalities in first-episode schizophrenia inferred from magnetization transfer imaging. Archives of General Psychiatry, 60(8), 779-788.
Baxter, R. D., and Liddle, P. F. (1998). Neuropsychological deficits associated with schizophrenic syndromes. Schizophrenia Research, 30, 239-249.
Beasley, C. L., Dwork, A. J., Rosoklija, G., Mann, J. J., Mancevski, B., Jakovski, Z., Davceva, N., Tait, A. R., Straus, S. K., and Honer, W. G. (2009). Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia. Schizophrenia Research, 109, 159-166.
Beck, A., and Steer, R. (1990). Manual for the Beck anxiety inventory. Psychological Corporation, San Antonio.
Beck, A., Ward, C., Mendelson, M., Mock, J., and Frbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-591.
Bottas, A., Cooke, R.G., and Richter, M.A. (2005). Comorbidity and pathophysiology of obsessive- compulsive disorder in schizophrenia: Is there evidence for a schizo-obsessive subtype of schizophrenia?. Journal of Psychiatry Neuroscience. 30(3), 187-193
Braff, D. L. (1985). Attention, habituation, and information processing in psychiatric disorders. Psychiatry. Philadelphia, PA: Lippinott, pp.1-13.
Brickenkamp, R. (2002). Test d2. Aufmerksamkeits -Belastungs-Test. Manual. 9. Auflage. Hogrefe, Göttingen.
Chen, W. J., Hsio, C. K., Hsio, L. L., and Hwu, H. G. (1998). Performance of the Continuous Performance Test among community samples. Schizophrenia Bulletin 24, 163-174.
Cornblatt, B. A., and Keilp, J. G. (1994). Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophrenia Bulletin 20, 31–46.
Cornblatt, B. A., and Malhotra, A. K. (2001). Impaired attention as an endophenotype for molecular genetic studies of schizophrenia. American Journal of Medical Genetics, 105, 11-15.
Cuttler, C., and Graf, P. (2007). Sub-clinical compulsive checkers’ prospective memory is impaired. Journal of Anxiety Disorders. 21(3), 338-352
Dickey, C. C., McCarley, R. W. Voglmaier, M. M., Niznikiewiez, M. A., Seidman, L. J., Hirayasu, Y. Fischer, I., Teh, E. K., Van Rhoads, R., Jakab, M., Kikinis, R., Jolescz, F. A., and Shenton, M. E. (1999). Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter. Biological Psychiatry 45, 1393-1402.
Dickey, C. C., McCarley, R. W., and Shenton, M. E. (2002). The brain in schizotypal personality disorder: a review of structural MRI and C T findings. Harvard Review of Psychiatry, 10, 1-15.
Dickey, C. C., McCarley, R. W., Xu, M. L., Seidman, L. J., Voglmaier, M. M., Niznikiewcz, M. A., Connor, E., and Shenton, M. E. (2007). MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder. Schizophrenia Research, 89, 49-58.
Eisen, J., and Rasmussen, D. (1993). Obsessive- compulsive disorder with psychotic features. Journal of Clinical Psychiatry, 54, 373-379.
First, M. B., Spitzer, R. L., Gibbson, M., and Williams, J. B. W. (1996). Structured clinical interview for DSM-IV Axis I disorder. New York: New York State Psychiatric Institute.
Frost, R. O., Steketee, G., Cohn, L., and Griess, K. (1994) Personality traits in subclinical and non- obsessive-compulsive volunteers and their parents. Behavior Research Theraphy 32(1), 47-56.
Gibbs, N. A. (1996). Nonclinical populations in research on obsessive-compulsive disorder: a critical review. Clinical Psychology Review 16(8), 729-773
Golden, C. J. (1978). Stroop Color and Word Test: A Manual for Clinical and Experimental Uses. Chicago, Illinois: Skoelting, 1-32.
Goodling, D. C., Kwapil, T. R., and Tallent, K. A. (1999). Wisconsin card sorting test deficits in schizotypic individuals. Schizophrenia Research, 40, 201-209.
Gooding, D. C., Matts, C. W., and Rollman, E. A. (2006). Sustained attention deficits in relation to psychometrically identified schizotypy: evaluating a potential endophenotypic marker. Schizophrenia Research, 82, 27-37.
Goodwin, A. H., and Sher K. J. (1992). Deficits in set-shifting ability in nonclinical compulsive checkers. Journal of Psychopathology and Behavior Assessment, 14, 81-91.
Gottesman, I. I., and Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry, 160, 636-645.
Gross-Isseroff, R., Sasson, Y., Voet, H., Hendler, T., Luca-Haimovici, K., Kandel-Sussman, H., and Zohar, J. (1996). Alternation learning in obsessive- compulsive disorder. Biological Psychiatry, 39, 733-738.
Hashimoto, R., Mori, T., Nemoto, K., Moriguchi, Y., Noguchi, H., Nakabayashi, T., Hori, H., Harada, S., Kunugi, H., Saitoh, O., and Ohnishi, T. (2009). Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging. World Journal of Biological Psychiatry, 10(1), 65-69.
Heaton, R. K., Chelune, G. J., Talley, J. L., Kay, G. G., and Curtiss, G. (1993). Wisconsin Card Sorting Test manual: revised and expanded. Odessa, Florida. Psychological Assessment Resources.
Hodgson, R. J., and Rachman, S. (1977). Obsessional -compulsive complaints. Behaviour Research and Therapy, 15, 389–395.
Joyal, C. C., Laakso, M. P., Tiihonen, J., Syvalahti, E., Vilkman, H., Laakso, A., Alakare, B., Rakkolainen, V., Salokangas, R.K., and Hietala, J. (2003). The amygdala and schizophrenia: a volumetric magnetic resonance imaging study in first-episode, neuroleptic -naive patients. Biological Psychiatry, 54, 1302-1304.
Kapur, S., and Remington, G. (1996). Serotonin- dopamine interaction and its relevance to schizophrenia. American Journal of Psychiatry, 153, 466-476.
Kim, M. S., Kang, S. S., Youn, T., Kang, D.H., Kim, J. J., and Kwon, J. S. (2003). Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder. Psychiatry Research: Neuroimaging. 123, 109-123.
Kim, M. S., Jang, K. M., and Kim, B. N. (2009). The neuropsyhcological profile of a subclinical obsessive- compulsive sample. Journal of the International Neuropsychological Society, 15, 286-290.
Kitis, A., Binnur, B., Akdede, K., Alptekin, K., Akvardar, Y., Arkar, H., Erol, A., and Kaya, N. (2007). Cognitive dysfunctions in patients with obsessive–compulsive disorder compared to the patients with schizophrenia patients: Relation to overvalued ideas. Progress in Neuro-Psychopharmacology & Biological Psychiatry 31, 254–261
Kozak, M. J., and Foa, E. B. (1994). Obsessions, overvalued ideas, and delusions in obsessive- compulsive disorder. Behaviour Research and Theraphy. 32, 343–353.
Kuelz, A.K., Hohagen, F., and Voderholzer, U. (2004). Neuropsychological performance in obsessive- compulsive disorder: a critical review. Biological Psychology 65, 185–236.
Laws, K. R. (1999). A meta-analytic review of Wisconsin Card Sorting studies in schizophrenia: general intellectual deficit in disguise? Journal of Experimental Psychology: Human perception and Performance, 29, 575-599.
Liddle, P. F., and Morris, D. L. (1991). Schizophrenic syndromes and frontal lobe performance. British Journal of Psychiatry, 158, 340-345.
Lin, H. F., Liu, Y. L., Liu, C. M., Hung, S. I., Hwu, H. G., and Chen, W. J. (2005). Neuregulin I gene and variations in perceptual aberration of schizotypal personality in adolescents. Psychological Medicine, 35, 1589-1598.
Martin, V., Huber, M., Rief, W., and Exner, C. (2008). Comparative cognitive profiles of obsessive- compulsive disorder and schizophrenia. Archives of Clinical Neuropsychology. 29, 1083-1093
Mataix-Cols, D., Junque, C., Sanchez-Turet, M., Vallejo, J., Verger, K., and Barrios, M. (1999). Neuropsychological Functioning in a Subclinical Obsessive-compulsive Sample. Biological Psychiatry 45, 898–904.
Matheson, S., and Langdon, R. (2008). Schizotypal traits impact upon executive working memory and aspects of IQ. Psychiatry Research, 159, 207-214.
McClure, M. M., Romero, M. J., Bowie, C. R., Reichenberg, A., Harvey, P. D., and Siever, L. J. (2007). Visual-spatial learning and memory in schizotypal personality disorder: continued evidence for the importance of working memory in the schizophrenia spectrum. Archives of Clinical Neuropsychology, 22, 109-116.
McDougle, C. J., Epperson, C. N., Pelton, G. H., Wasylink, S., and Price, L. H. (2000). A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Archives of General Psychiatry, 57, 794-801.
Meyers, J., and Meyers, K. (1995). Rey Complex Figure and Recognition Trial: Professional manual. Odessa, FL: Psychological Assessment Resources.
Michie, P. T., Kent, A., Stienstra, R., Castine, R., Johnston, J., Dedman, K., Wichmann, H., Box, J., Rock, D., Rutherford, E., and Jablensky, A. (2000). Phenotypic markers as risk factors in schizophrenia: neurocognitive functions. Australian and New Zealand Journal of Psychiatry, 34, 74-85.
Mitropoulou, V., Harvery, P. D., Zegarelli, G., New, A. S., Silverman, J. M., and Siever, L. J. (2005). Neuropsychological performance in schizotypal personality disorder: importance of working memory. American Journal of Psychiatry 162, 1896-1903.
Moorhead, T. W. J., Stanfield, A., Spencer, M., Hall, J., McIntosh, A., Qwnes, D. C., Lawrie, S., and Johnstone, E. (2009). Progressive temporal lobe gray matter loss in adolescents with schizotypal traits and mild intellectual impairment. Psychiatry Research: Neuroimaging, 174, 105-109.
Nakamura, M., McCarley, R. W., Kubicki, M., Dickey, C. C., Niznikiewicz, M. A., Voglmaier, M. M., Seidman, L. J., Maier, S. E., Westin, C., Kikinis, R., and Shenton, M. E. (2005). Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging study. Biological Psychiatry, 58, 468-478.
Neziroglu, F., McKay, D., Yaryura-Tobias, J. A., Stevens K. P., and Torado, J. (1999). The overvalued ideas scale: development, reliability and validity in obsessive compulsive disorder. Behaviour Research and Theraphy. 37, 881-902.
Noguchi, H., Hori, H., and Kunugi, H. (2008). Schizotypal traits and cognitive function in healthy adults. Psychiatry Research, 161, 162-169.
Nuechterlein, K. H., and Dawson, M. E. (1984). Information processing and attentional function in the developmental course of schizophrenia disorder. Schizophrenia Bulletin, 10, 160-203.
Okasha, A., Rafaat, M., Mahallawy, N., El Nahas, G., El Dawla, A. S., Sayed, M., and El Khpli, S. (2000). Cognitive dysfunction in obsessive- compulsive disorder. Acta Psychiatrica Scandinavica, 101, 281-285.
Olley, A., Malhi, G., and Sachdev, P. (2007). Memory and executive function in obsessive-compulsive disorder: A selective review. Journal of Affective Disorders, 104, 15-23.
Osterrieth, P. A., (1944). Le test du copie d’une figure complex: contribution à l’étude de la perception et de la memoire (The test of copying a complex figure: a contribution to the study of perception and memory). Archives of Psychology 30, 286–350.
Perry W., Geyer M., Cadenhead K., Swerdlow N., Braff D. (1997). Schizophrenic patients with normal prepulse inhibition? In: Nasrallah H., Delisi L., editors. the Ⅵth International Congress on Schizophrenia Research. Colorado Springs, Colorado: Elsevier, p. 231.
Poyurovsky, M. D., Fuchs, C., and Weizman, A. (1999). Obsessive-compulsive disorder in patients with first-episode schizophrenia. American Journal of Psychiatry, 156, 1998-2000.
Ragland, J. D., Laird, A. R., Ranganath, C., Blumenfeld, R.S., Gonzales, S. M., and Glahn, D. C. (2009). Prefrontal activation deficits during episodic memory in schizophrenia. American Journal of Psychiatry, 166, 863-874.
Raine, A. (1991). The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin. 17, 555-564.
Raine, A., Phil, D., and Benishay, D. (1995). The SPQ-B: a brief screening instrument for schizotypal personality disorder. Journal of Personality Disorders. 9(4), 346-355
Rauch, S.L. (2000). Neuroimaging research and neurobiology of obsessive-compulsive disorder: where do we go from here? Biological Psychiatry, 47, 168-170.
Rey, A. (1941). L’examine psychologique dans les cas d’encephalopathie traumatique. Archives de Psychologie, 28, 286–340.
Roh, K. S., Shin, M. S., Kim, M. S., Ha, T. H., Shin, Y. W., Lee, K. J., and Kwon, J. S. (2005). Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: a naturalistic study. Psychiatry and Clinical Neurosciences, 59, 539-545.
Roth, R. M., and Baribeau, J. (2000). The relationship between schizotypal and obsessive-compulsive features in university students. Personality And Individual Differences. 29, 1083-1093
Sanavio, E. (1988). Obsessions and compulsions: The Padua Inventory. Behaviour Research and Therapy, 26, 169-177.
Saykin, A. J., Gur, R. C., and Gur, R. E. (1991). Neuropsychological functioning in schizophrenia: selective impairment in memory and learning. Archives of General Psychiatry, 48, 618-624.
Sher K. J., and Mann, B. (1984). Cognitive dysfunction in compulsive checkers: further explorations. Behaviour Research and Therapy, 22, 493-502.
Siever, L. J., and Davis, K. L. (2004). The pathophysiology of schizophrenia disorders: perspectives from the spectrum. American Journal of Psychiatry 161, 398 -413.
Spitznagel, M. B., and Suhr, J. A., (2002). Executive function deficits associated with symptoms of schizotypy and obsessive-compulsive disorder. Psychiatry Research, 110, 151–163.
Stein, D. J. (2002). Obsessive–compulsive disorder. Lancet, 360, 397-405.
Szoke, A., Meary, A., Ferchiou, A., Trandafir, A., Leboyer, M., and Schurhoff, F. (2009). Correlations between cognitive performances and psychotic or schizotypal dimensions. European Psychiatry, 24, 244-250.
Thomsen, P. H., and Jensen, J. (1994). Obsessive -compulsive disorder: admission patterns and diagnostic stability. A case register study. Acta Psychiatrica Scandinavica, 90, 19-24.
Tibbo, P., and Warneke, L., (1999). Obsessive- compulsive disorder in schizophrenia: epidemiologic and biologic overlap. Journal of Psychiatry and Neuroscience, 24, 15–24.
Voglmaier M. M., Seidman, L. J., Niznikiewicz M. A., Dickey C. C., Shenton M. E., and McCarley R. W. (2000). Verbal and nonverbal neuropsychological test performance in subjects with schizotypal personality disorder. American Journal of Psychiatry, 157, 787-793.
Voglmaier, M. M., Seidman, L. J., Niznikiewicz, M. A., Dickey, C. C., Shenton, M. E., and McCarley, R.W. (2005). A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder. Schizophrenia Research, 74, 43-49.
Whitney, K. A., Fastenau, P. S., Evansa, J. D., and Lysaker, P. H. (2004). Comparative neuropsychological function in obsessive-compulsive disorder and schizophrenia with and without obsessive-compulsive symptoms. Schizophrenia Research, 69, 75–83
Wilson, C. M., Christensen, B. K., King, J. P., Li, Q., and Zelazo, P. D. (2008). Decomposing perseverative errors among undergraduates scoring high on the schizotypal personality questionnaire. Schizophrenia Research, 106, 3-12.