The Basic Semantic Register(BSR) is and official ISO register designed for interoperability among eBusiness and EDI systems. The entities registered in the current BSR are not defined in a machine-understandable way, which renders automatic extraction of structural and relationship information from the register impossible. The purpose of this study is to offer a framework for designing an ontology that can provide semantic interoperability among BSR-based systems by defining data structures and relationships with RDF and OWL, similar meaning by the 'equivalentClass' construct in OWL, the hierachical relationships among classes by the 'subClassOf' construct in RDF schema, definition of any entities in BSR by the 'label' construct in RDF schema, specification of usage guidelines by the 'comment' construct in RDF schema, assignment of classes to BSU's by the 'domain' construct in RDF schema, specification of data types of BSU's by the 'range' construct in RDF schema. Hierarchical relationships among properties in BSR can be expressed using the 'subPropertyOf' in RDF schema. Progress in semantic interoperability can be expected among BSR-based systems through applications of semantic web technology suggested in this study.