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Amphetamine-type Stimulants in Drug Testing
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2019, v.10 no.1, pp.1-10
https://doi.org/10.5478/MSL.2019.10.1.1
(Chungnam National University)
(National Forensic Service)
(National Forensic Service)
Chung,
H., &
Choe,
S.
(2019). Amphetamine-type Stimulants in Drug Testing. Mass Spectrometry Letters, 10(1), 1-10, https://doi.org/10.5478/MSL.2019.10.1.1
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Abstract
Amphetamine-type stimulants (ATS) are a group of β-phenethylamine derivatives that produce central nervous sys-tem stimulants effects. The representative ATS are methamphetamine and 3, 4-methylenedioxymethamphetamine (MDMA), and abuse of ATS has become a global problem. Methamphetamine is abused in North America and Asia, while amphetamine and 3, 4-methyl e nedioxy m ethamphetamine (Ecstasy) are abused in Europe and Australia. Methamphetamine is also the most abused drug in Korea. In addition to the conventional ATS, new psychoactive substances (NPS) including phenethylamines and synthetic cathinones, which have similar effects and chemical structure to ATS, continue to spread to the global market since 2009, and more than 739 NPS have been identified. For the analysis of ATS, two tests that have different theoretical principles have to be conducted, and screening tests by immunoassay and confirmatory tests using GC/MS or LC/MS are the global stan-dard methods. As most ATS have a chiral center, enantiomer separation is an important point in forensic analysis, and it can be conducted using chiral derivatization reagents or chiral columns. In order to respond to the growing drug crime, it is necessary to develop a fast and efficient analytical method.
- keywords
- Amphetamine-type stimulants, ATS, methamphetamine, new psychoactive substances, NPS
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- Submission Date
- 2018-09-02
- Revised Date
- 2018-12-18
- Accepted Date
- 2018-12-18
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