- P-ISSN 2233-4203
- E-ISSN 2093-8950
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI, SCOPUS, KCI
Article Detail
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Oligomer Complexes of the (VQIVYK + NNQQNY) and (VQIVYK + LYQLEN) Mixing Solutions
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2019, v.10 no.1, pp.32-37
https://doi.org/10.5478/MSL.2019.10.1.32
(Department of Applied Chemistry, Kumoh National In)
(Department of Applied Chemistry, Kumoh National Institute of Technology)
(Department of Applied Chemistry, Kumoh National Institute of Technology)
(Department of Applied Chemistry, Kumoh National Institute of Technology)
(Department of Applied Chemistry, Kumoh National Institute of Technology)
Jung,
Y., Shin,
M., &
Kim,
H.
(2019). Oligomer Complexes of the (VQIVYK + NNQQNY) and (VQIVYK + LYQLEN) Mixing Solutions. Mass Spectrometry Letters, 10(1), 32-37, https://doi.org/10.5478/MSL.2019.10.1.32
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Abstract
The π-π interactions of the peptide-dimer and peptide-trimer complexes were investigated in the (VQIVYK + LYQLEN) and (VQIVYK + NNQQNY) mixing solutions. The results showed that tyrosine (Y) residues were critical in the for-mation of hetero peptide-dimers and -trimers during the early oligomerization process. We used collision-induced dissociation (CID) along with electrospray ionization mass spectroscopy (ESI-MS) to obtain the structural information of the hetero-dimers and -trimers. We chose three amyloidogenic peptides–VQIVYK, NNQQNY, and LYQLEN–from tau protein, yeast prion-like protein Sup35, and insulin chain A, respectively. Hetero-dimer, -trimer, -tetramer, and -pentamer complexes were observed in the mass spectra. The tandem mass spectrum of the hetero-dimer and hetero-trimer showed two different fragmentation patterns (covalent and non-covalent bond dissociation). Y-Y interaction structures were also proposed for the hetero-dimer and -trimer complexes.
- keywords
- Peptide oligomer, VQIVYK, NNQQNY, LYQLEN, mass spectrometry (MS), MS/MS
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- Submission Date
- 2018-12-17
- Revised Date
- 2019-01-19
- Accepted Date
- 2019-01-22
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