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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Hydrolysis of Penicillin G and Carbenicillin in Pure Water - As Studied by HPLC/ESI-MS

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2019, v.10 no.4, pp.108-111
https://doi.org/10.5478/MSL.2019.10.4.108
Marta Kołek (Mickiewicz University)
Rafał Frański (Mickiewicz University)
Magdalena Frańska (Poznań University of Technology)
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Abstract

The hydrolysis of penicillin G, carbenicillin and ampicillin in pure water at room temperature was studied by high pressure liquid chromatography electrospray ionization mass spectrometry. Hydrolysis of ampicillin did not occur under these conditions; however, penicillin G and carbenicillin were completely hydrolyzed after seven days. A short interpretation of this difference is proposed. The mass spectrometric behaviour, namely ESI response and fragmentation pathway, of hydrolyzed pen- icillin G and hydrolyzed carbenicillin have been also discussed.

keywords
penicillin, carbenicillin, hydrolysis, mass spectrometry, electrospray, liquid chromatography


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투고일Submission Date
2019-09-24
수정일Revised Date
2019-11-21
게재확정일Accepted Date
2019-12-01
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Mass Spectrometry Letters