- P-ISSN 2233-4203
- E-ISSN 2093-8950
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI, SCOPUS, KCI
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Hydrolysis of Penicillin G and Carbenicillin in Pure Water - As Studied by HPLC/ESI-MS
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2019, v.10 no.4, pp.108-111
https://doi.org/10.5478/MSL.2019.10.4.108
(Mickiewicz University)
(Mickiewicz University)
(Poznań University of Technology)
(Mickiewicz University)
(Poznań University of Technology)
Kołek,
M., Frański,
R., &
Frańska,
M.
(2019). Hydrolysis of Penicillin G and Carbenicillin in Pure Water - As Studied by HPLC/ESI-MS. Mass Spectrometry Letters, 10(4), 108-111, https://doi.org/10.5478/MSL.2019.10.4.108
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Abstract
The hydrolysis of penicillin G, carbenicillin and ampicillin in pure water at room temperature was studied by high pressure liquid chromatography electrospray ionization mass spectrometry. Hydrolysis of ampicillin did not occur under these conditions; however, penicillin G and carbenicillin were completely hydrolyzed after seven days. A short interpretation of this difference is proposed. The mass spectrometric behaviour, namely ESI response and fragmentation pathway, of hydrolyzed pen- icillin G and hydrolyzed carbenicillin have been also discussed.
- keywords
- penicillin, carbenicillin, hydrolysis, mass spectrometry, electrospray, liquid chromatography
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- Submission Date
- 2019-09-24
- Revised Date
- 2019-11-21
- Accepted Date
- 2019-12-01
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