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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN2233-4203
  • E-ISSN2093-8950
  • ESCI, SCOPUS, KCI

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Chiral Derivatization of Hydroxycarboxylic Acids Using 2,4,6-Trichlorobenzoyl Chloride as a Highly Efficient Regioselective Esterification Reagent for Gas Chromatography-Mass Spectrometry

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2020, v.11 no.4, pp.103-107
https://doi.org/10.5478/MSL.2020.11.4.103
Jeong Hyeok Park (Department of Chemistry, Gachon University)
Sang Yun Han (Department of Chemistry, Gachon University)
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Abstract

We report the application of 2,4,6-trichlorobenzoyl chloride (often referred to as Yamaguchi esterification reagent) for the selective derivatization of the carboxylic group for GC-MS with the sample preparation method optimized for GC-MS analysis. The reagent was shown to be capable of selectively turning the carboxylic group into a reaction center, i.e., anhydride, of which the further reaction was directed to a near complete formation of required esters by unique steric and electronic effects of the reagent. Using the developed method, the chiral separation of hydroxycarboxylic acids by GC-MS using non-chiral col-umns was successfully demonstrated.

keywords
2, 4, 6-trichlorobenzoyl chloride, chiral separation, GC-MS, hydroxycarboxylic acids, O-acetylated L-menthyl esters


투고일Submission Date
2020-12-14
수정일Revised Date
2020-12-23
게재확정일Accepted Date
2020-12-23
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Mass Spectrometry Letters