- P-ISSN 2233-4203
- E-ISSN 2093-8950
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI, SCOPUS, KCI
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Advances in Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS)-Based Techniques for Elucidating Higher-Order Protein Structures
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2020, v.11 no.4, pp.65-70
https://doi.org/10.5478/MSL.2020.11.4.65
(Pohang University of Science and Technology (POSTECH))
Seo,
J.
(2020). Advances in Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS)-Based Techniques for Elucidating Higher-Order Protein Structures. Mass Spectrometry Letters, 11(4), 65-70, https://doi.org/10.5478/MSL.2020.11.4.65
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Abstract
Despite its great success in the field of proteomics, mass spectrometry has limited use for determining structural details of peptides, proteins, and their assemblies. Emerging ion mobility spectrometry-mass spectrometry has enabled us to explore the conformational space of protein ions in the gas phase, and further combinations with the gas-phase ion spectroscopy and the colli-sion-induced unfolding have extended its abilities to elucidating the secondary structure and local details of conformational transi-tions. This review will provide a brief introduction to the combined approaches of IMS-MS with gas-phase ion infrared spectroscopy or collision-induced unfolding and their most recent results that successfully revealed higher-order structural details.
- keywords
- protein structure, ion mobility spectrometry-mass spectrometry, ion spectroscopy, collision-induced unfolding
- Submission Date
- 2020-09-13
- Revised Date
- 2020-11-13
- Accepted Date
- 2020-11-17
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