• P-ISSN2233-4203
  • E-ISSN2093-8950

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

A Simple Method for Determining Residual p-arsanilic Acid in Aquatic Products using EDTA-Assisted Solvent Extraction and LC-MRM

Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2023, v.14 no.2, pp.36-41
Kwon Min Kyeong (College of Pharmacy, Dankook University)
Shin Ye Bin (College of Pharmacy, Dankook University)
Kim Young Min (College of Pharmacy, Dankook University)
Kim Jin Hwan (College of Pharmacy, Dankook University)
Kim Ji Seong (College of Pharmacy, Dankook University)
Choi Yong Seok (College of Pharmacy, Dankook University)
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A simple method was developed to determine residual p-arsanilic acid (ASA), an organo-arsenic compound used as a feed additive, in aquatic products (eel, halibut, and shrimp) using EDTA-assisted solvent extraction and LC-MRM. The method was successfully validated in terms of specificity, linearity (coefficient of determination ≥ 0.995), accuracy (recovery or R, 72.72-78.73%), precision (the relative standard deviation of R, 2.08-6.98%), and sensitivity (the lower limit of quantitation, 5 ppb) according to CODEX guidelines (CAC-GL 71-2009). The use of EDTA in the extraction solvent and water with a suitable pH modifier as the reconstitution solvent may be the key factors for successful results. This is the first method that can be used for monitoring residual ASA in aquatic products using LC-MRM and could contribute to establishing a better aquatic product safety management system.

p-arsanilic acid MRM EDTA solvent extraction halibut eel shrimp aquatic products

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Mass Spectrometry Letters