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  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN2233-4203
  • E-ISSN2093-8950
  • ESCI, SCOPUS, KCI

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Simultaneous Determination of Synthetic Phosphodiesterase-5 Inhibitors in Dietary Supplements by Liquid Chromatography-High Resolution/Mass Spectrometry

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2012, v.3 no.2, pp.50-53
https://doi.org/10.5478/MSL.2012.3.2.50
So-Hee Kim (Korea Institute of Science and Technolog)
Ho Jun Kim (Korea Institute of Science and Technology)
Junghyun Son (Korea Institute of Science and Technolog)
Byoung Wook Jeon (Korea Institute of Science and Technolog)
Eun Sook Jeong (Inje University)
Eun Ju Cha (Korea Institute of Science and Technolog)
Jaeick Lee (Korea Institute of Science and Technolog)
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Abstract

After success of sildenafil for the treatment of erectile dysfunction, a large number of its analogues have beenapproved from FDA. Recently, the illegal dietary supplements which include sildenafil, vardenafil, tadalafil, or analogues ofthese drugs as ingredient have been widely distributed. Therefore, the determination of the residue of synthetic phosphodiesterase-5 (PDE-5) inhibitors in dietary supplements is highly required due to indiscriminate and unintentional overdose causednausea, chest pains, fainting and irregular heartbeat. In this paper, we report a rapid and sensitive analytical method for thesimultaneous determination of nine phosphodiesterase-5 inhibitors by liquid chromatography-high resolution mass spectrometry. The present method was found to be accurate and reproducible with 40 μg/g of the limit of quantification for the nine PDE-5inhibitors. The developed method can be successfully applied to the analysis of the seven illegal dietary supplements.

keywords
LC-HR/MS, LTQ-Orbitrap, Phosphodiesterase-5 inhibitor, Sildenafil


참고문헌

1

Palit, V. (2010). . Nat. Rev. Urol, 7, 603-.

2

Reepmeyer, J. C. (2007). . J. Pharmaceut. Biomed, 44, 887-.

3

Reepmeyer, J. C. (2009). . J. Pharmaceut. Biomed, 49, 145-.

4

Hou, P. L. (2006). . Food Addit. Contam, 23, 870-.

5

Balayssac, S. (2009). . J. Pharmaceut. Biomed, 50, 602-.

6

Ahn, S. (2009). . Rapid Commun. Mass Spectrom, 23, 3158-.

7

Liang, Q. L. (2006). . J. Pharmaceut. Biomed, 40, 305-.

8

Man, C. N. (2009). . J. Chromatogr. A, 1216, 8426-.

9

Gryniewicz, C. M. (2009). . J. Pharmaceut. Biomed, 49, 601-.

10

Jaesung Pyo. (2012). Determination of the PDE-5 Inhibitors and Their Analogues by GC-MS and TMS Derivatization. Mass Spectrometry Letters, 3(1), 15-17. http://dx.doi.org/10.5478/MSL.2012.3.1.015.

11

Bogusz, M. J. (2006). . J. Pharmaceut. Biomed, 41, 554-.

12

Zhang, Y. (2010). . J. Sep. Sci, 33, 2109-.

13

Gratz, S. R. (2006). . Rapid Commun. Mass Spectrom, 20, 2317-.

14

van der Heeft, E. (2009). . J. Am. Soc. Mass Spectrom, 20, 451-.

15

Holman, S. W. (2010). . J. Anal. Chem, 82, 2347-.

투고일Submission Date
2012-05-29
수정일Revised Date
2012-06-19
게재확정일Accepted Date
2012-06-19
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