- P-ISSN 2233-4203
- E-ISSN 2093-8950
- 권한신청
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI
논문 상세
Home > 논문 상세
Simultaneous Determination of Synthetic Phosphodiesterase-5 Inhibitors in Dietary Supplements by Liquid Chromatography-High Resolution/Mass Spectrometry
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2012, v.3 no.2, pp.50-53
https://doi.org/10.5478/MSL.2012.3.2.50
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technology)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technolog)
(Inje University)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technology)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technolog)
(Inje University)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technolog)
Kim,
S.,
Kim,
H. J.,
Son,
J.,
Jeon,
B. W.,
Jeong,
E. S.,
Cha,
E. J.,
&
Lee,
J.
(2012). . Mass Spectrometry Letters, 3(2), 50-53, https://doi.org/10.5478/MSL.2012.3.2.50
- 다운로드 수
- 조회수
Abstract
After success of sildenafil for the treatment of erectile dysfunction, a large number of its analogues have beenapproved from FDA. Recently, the illegal dietary supplements which include sildenafil, vardenafil, tadalafil, or analogues ofthese drugs as ingredient have been widely distributed. Therefore, the determination of the residue of synthetic phosphodiesterase-5 (PDE-5) inhibitors in dietary supplements is highly required due to indiscriminate and unintentional overdose causednausea, chest pains, fainting and irregular heartbeat. In this paper, we report a rapid and sensitive analytical method for thesimultaneous determination of nine phosphodiesterase-5 inhibitors by liquid chromatography-high resolution mass spectrometry. The present method was found to be accurate and reproducible with 40 μg/g of the limit of quantification for the nine PDE-5inhibitors. The developed method can be successfully applied to the analysis of the seven illegal dietary supplements.
- keywords
- LC-HR/MS, LTQ-Orbitrap, Phosphodiesterase-5 inhibitor, Sildenafil
참고문헌
1
Palit, V. (2010). . Nat. Rev. Urol, 7, 603-.
2
Reepmeyer, J. C. (2007). . J. Pharmaceut. Biomed, 44, 887-.
3
Reepmeyer, J. C. (2009). . J. Pharmaceut. Biomed, 49, 145-.
4
Hou, P. L. (2006). . Food Addit. Contam, 23, 870-.
5
Balayssac, S. (2009). . J. Pharmaceut. Biomed, 50, 602-.
6
Ahn, S. (2009). . Rapid Commun. Mass Spectrom, 23, 3158-.
7
Liang, Q. L. (2006). . J. Pharmaceut. Biomed, 40, 305-.
8
Man, C. N. (2009). . J. Chromatogr. A, 1216, 8426-.
9
Gryniewicz, C. M. (2009). . J. Pharmaceut. Biomed, 49, 601-.
10
Jaesung Pyo. (2012). Determination of the PDE-5 Inhibitors and Their Analogues by GC-MS and TMS Derivatization. Mass Spectrometry Letters, 3(1), 15-17. http://dx.doi.org/10.5478/MSL.2012.3.1.015.
11
Bogusz, M. J. (2006). . J. Pharmaceut. Biomed, 41, 554-.
12
Zhang, Y. (2010). . J. Sep. Sci, 33, 2109-.
13
Gratz, S. R. (2006). . Rapid Commun. Mass Spectrom, 20, 2317-.
14
van der Heeft, E. (2009). . J. Am. Soc. Mass Spectrom, 20, 451-.
15
Holman, S. W. (2010). . J. Anal. Chem, 82, 2347-.
- 투고일Submission Date
- 2012-05-29
- 수정일Revised Date
- 2012-06-19
- 게재확정일Accepted Date
- 2012-06-19
권호 내 다른 논문
- Gas Chromatography-High Resolution Tandem Mass Spectrometry Using a GC-APPI-LIT Orbitrap for Complex Volatile Compounds Analysis
- An Application of Electrostatic Repulsion Hydrophilic Interaction Chromatography in Phospho- and Glycoproteome Profiling of Epicardial Adipose Tissue in Obesity Mouse
- Application of Comprehensive 2D GC-MS and APPI FT-ICR MS for More Complete Understanding of Chemicals in Diesel Fuel
- Microwave-assisted Weak Acid Hydrolysis of Proteins
- Simultaneous Determination of Synthetic Phosphodiesterase-5 Inhibitors in Dietary Supplements by Liquid Chromatography-High Resolution/Mass Spectrometry
- Isotope Measurement of Uranium at Ultratrace Levels Using Multicollector Inductively Coupled Plasma Mass Spectrometry
- Determination of Mercury in Fly Ash by Using Flow Injection Cold Vapor Isotope Dilution Inductively Coupled Plasma Mass Spectrometry
- more
추천 논문
학술지 홈페이지 이용 환경은 크롬 브라우저 사용을 권장합니다.