- P-ISSN 2233-4203
- E-ISSN 2093-8950
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI, SCOPUS, KCI
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Simultaneous Determination of Synthetic Phosphodiesterase-5 Inhibitors in Dietary Supplements by Liquid Chromatography-High Resolution/Mass Spectrometry
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2012, v.3 no.2, pp.50-53
https://doi.org/10.5478/MSL.2012.3.2.50
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technology)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technolog)
(Inje University)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technology)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technolog)
(Inje University)
(Korea Institute of Science and Technolog)
(Korea Institute of Science and Technolog)
Kim,
S., Kim,
H. J., Son,
J., Jeon,
B. W., Jeong,
E. S., Cha,
E. J., &
Lee,
J.
(2012). Simultaneous Determination of Synthetic Phosphodiesterase-5 Inhibitors in Dietary Supplements by Liquid Chromatography-High Resolution/Mass Spectrometry. Mass Spectrometry Letters, 3(2), 50-53, https://doi.org/10.5478/MSL.2012.3.2.50
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Abstract
After success of sildenafil for the treatment of erectile dysfunction, a large number of its analogues have beenapproved from FDA. Recently, the illegal dietary supplements which include sildenafil, vardenafil, tadalafil, or analogues ofthese drugs as ingredient have been widely distributed. Therefore, the determination of the residue of synthetic phosphodiesterase-5 (PDE-5) inhibitors in dietary supplements is highly required due to indiscriminate and unintentional overdose causednausea, chest pains, fainting and irregular heartbeat. In this paper, we report a rapid and sensitive analytical method for thesimultaneous determination of nine phosphodiesterase-5 inhibitors by liquid chromatography-high resolution mass spectrometry. The present method was found to be accurate and reproducible with 40 μg/g of the limit of quantification for the nine PDE-5inhibitors. The developed method can be successfully applied to the analysis of the seven illegal dietary supplements.
- keywords
- LC-HR/MS, LTQ-Orbitrap, Phosphodiesterase-5 inhibitor, Sildenafil
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- Submission Date
- 2012-05-29
- Revised Date
- 2012-06-19
- Accepted Date
- 2012-06-19
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