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- E-ISSN 2093-8950
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Diagnostic Evaluation of Enzyme Activity Related to Steroid Metabolism by Mass Spectrometry-Based Steroid Profiling
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2014, v.5 no.2, pp.35-41
https://doi.org/10.5478/MSL.2014.5.2.35
(Korea Institute of Science and Technology)
(Korea Institute of Science and Technology)
(Korea Institute of Science and Technology)
Cho,
M. H., &
Chung,
B.
C.
(2014). Diagnostic Evaluation of Enzyme Activity Related to Steroid Metabolism by Mass Spectrometry-Based Steroid Profiling. Mass Spectrometry Letters, 5(2), 35-41, https://doi.org/10.5478/MSL.2014.5.2.35
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Abstract
Gas chromatography-mass spectrometry (GC-MS) methods have been used extensively in clinical steroid analyses. Evaluating the metabolic ratios of precursors to products by accurate quantification of individual steroid levels in biologicalsamples can reveal the activities of enzymes associated with steroid metabolism. This review article discusses the impact of GCMS-based steroid profiling on our understanding of the biochemical role of steroids and their metabolic enzymes in hormonedependentdiseases, such as congenital adrenal hyperplasia (CAH), cortisol-mediated hypertension, apparent mineralocorticoidexcess (AME), male-pattern baldness, and breast and thyroid cancers. Steroid profiling is a comprehensive analytical techniquethat can be applied whenever the highest specificity is required and may be a reasonable initial diagnostic approach.
- keywords
- steroid, metabolite profiling, biomarker, clinical diagnosis, steroidogenesis
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- Submission Date
- 2014-05-27
- Revised Date
- 2014-06-05
- Accepted Date
- 2014-06-05
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