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- E-ISSN 2093-8950
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Soft Ionization of Metallo-Mefenamic Using Electrospray Ionization Mass Spectrometry
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2015, v.6 no.2, pp.43-47
https://doi.org/10.5478/MSL.2015.6.2.43
(National Sun Yat-Sen University,Assuit University, Assuit)
(National Sun Yat-Sen University)
(National Sun Yat-Sen University)
Abdelhamid,
H. N., &
Wu,
H.
(2015). Soft Ionization of Metallo-Mefenamic Using Electrospray Ionization Mass Spectrometry. Mass Spectrometry Letters, 6(2), 43-47, https://doi.org/10.5478/MSL.2015.6.2.43
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Abstract
Detection of mefenamic acid (M, non-steroidal anti-inflammatory drug, NSAIDs) and its metallodrug was investigated using electrospray ionization mass spectrometry (ESI-MS) and fluorescence spectroscopy. ESI-MS data (500 μL, 1×10-3 M) revealed high detection sensitivity for the drug and metallodrug. ESI-MS spectra revealed peaks at 242, 580, and 777 Da corresponding to [M+H]+, [63Cu(M-H)2(H2O)2+H]+, and [56Fe(M-H)3+H]+, respectively. The metal:mefenamic ratios of ESIMS spectra are in complete agreement with the fluorescence spectroscopy results (1:2 for Cu(II) and 1:3 for Fe(III)). ESI is a soft ionization technique that can be used on labile metallo-mefenamic acids and is promising for the detection of these species in environmental samples and biological fluids.
- keywords
- Mefenamic Acid, Metallodrug, ESI-MS, Fluorescence spectroscopy
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- Submission Date
- 2015-03-15
- Revised Date
- 2015-05-15
- Accepted Date
- 2015-05-26
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