- P-ISSN 2233-4203
- E-ISSN 2093-8950
- Log In/Sign Up
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI, SCOPUS, KCI
Article Detail
Home > Article Detail
Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2015, v.6 no.2, pp.48-51
https://doi.org/10.5478/MSL.2015.6.2.48
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Huazhong University)
(Huazhong University)
(Huazhong University)
(Kunming Institute of Botany)
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Huazhong University)
(Huazhong University)
(Huazhong University)
(Kunming Institute of Botany)
(Hanyang University)
Rehman,
S. U., Kim,
I. S., Choi,
M. S., Luo,
Z., Yao,
G., Zhang,
Y., Xue,
Y. B., &
Yoo,
H.
H.
(2015). Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes. Mass Spectrometry Letters, 6(2), 48-51, https://doi.org/10.5478/MSL.2015.6.2.48
- Downloaded
- Viewed
Abstract
Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.
- keywords
- kinsenoside, stability, liver microsomes
Reference
1
Du, X. M.. (2008). . J. Nat. Med, 62, 132-.
2
Du, X.. (2001). . Biol. Pharm. Bull, 24, 65-.
3
Zhang, Y.. (2007). . J. Ethnopharmacol, 114, 141-.
4
Hsiao, H. B.. (2011). . Shock, 35, 184-.
5
Shih, C. C.. (2002). . Clin. Exp. Pharmacol. Physiol, 29, 684-.
6
Wu, J. B.. (2007). . Res, 21, 58-.
7
Hsiao, H. B.. (2013). . Osteoporis. Int, 24, 1663-.
8
Liu, Z. L.. (2013). . Fitoterapia, 86, 163-.
9
Masimirembwa, C. M.. (2001). . Comb. Chem. High Throughput Screen, 4, 245-.
- Submission Date
- 2015-05-08
- Revised Date
- 2015-05-28
- Accepted Date
- 2015-06-01
Other articles from this issue
- Sample Preparation for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
- Enrichment Strategies for Identification and Characterization of Phosphoproteome
- Identification of Degradation Products in the Phosphodiesterase (PDE-4) Inhibitor Roflumilast Using High Resolution Mass Spectrometry and Density Functional Theory Calculations
- Soft Ionization of Metallo-Mefenamic Using Electrospray Ionization Mass Spectrometry
- Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes
- Investigation on Lipopolysaccharide Activated Microglia by Phosphoproteomics and Phosphoinositide Lipidomics
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.