- P-ISSN 2233-4203
- E-ISSN 2093-8950
- 권한신청
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI
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Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2015, v.6 no.2, pp.48-51
https://doi.org/10.5478/MSL.2015.6.2.48
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Huazhong University)
(Huazhong University)
(Huazhong University)
(Kunming Institute of Botany)
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Huazhong University)
(Huazhong University)
(Huazhong University)
(Kunming Institute of Botany)
(Hanyang University)
Rehman,
S. U.,
Kim,
I. S.,
Choi,
M. S.,
Luo,
Z.,
Yao,
G.,
Zhang,
Y.,
Xue,
Y. B.,
&
Yoo,
H.
H.
(2015). . Mass Spectrometry Letters, 6(2), 48-51, https://doi.org/10.5478/MSL.2015.6.2.48
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Abstract
Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.
- keywords
- kinsenoside, stability, liver microsomes
참고문헌
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- 투고일Submission Date
- 2015-05-08
- 수정일Revised Date
- 2015-05-28
- 게재확정일Accepted Date
- 2015-06-01
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