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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN2233-4203
  • E-ISSN2093-8950
  • ESCI, SCOPUS, KCI

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  • P-ISSN 2233-4203
  • E-ISSN 2093-8950

Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes

Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2015, v.6 no.2, pp.48-51
https://doi.org/10.5478/MSL.2015.6.2.48
Shaheed Ur Rehman (Hanyang University)
In Sook Kim (Hanyang University)
Min Sun Choi (Hanyang University)
Zengwei Luo (Huazhong University)
Guangming Yao (Huazhong University)
Yonghui Zhang (Huazhong University)
Yong Bo Xue (Kunming Institute of Botany)
Hye Hyun Yoo (Hanyang University)
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Abstract

Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.

keywords
kinsenoside, stability, liver microsomes


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투고일Submission Date
2015-05-08
수정일Revised Date
2015-05-28
게재확정일Accepted Date
2015-06-01
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Mass Spectrometry Letters