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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN1225-0163
  • E-ISSN2288-8985
  • SCOPUS, ESCI, KCI

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  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

논문 상세

    Development of Jaspine B analysis using LC-MS/MS and its application: Dose-independent pharmacokinetics of Jaspine B in rats

    분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
    2021, v.34 no.2, pp.37-45
    https://doi.org/10.5806/AST.2021.34.2.37
    Im-Sook Song (Kyungpook National University)
    Ji-Hyeon Jeon (Kyungpook National University)
    이지훈 (경북대학교 약학연구소)
    Dong Yu Lim (College of Pharmacy, Dankook University,)
    Chul Haeng Lee (College of Pharmacy, Dankook University)
    Dongjoo Lee (College of Pharmacy, Ajou University)
    Min-Koo Choi (College of Pharmacy, Dankook University)
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    Abstract

    A rapid and simple LC-MS/MS analytical method in determining Jaspine B has been developed and validated in rat plasma. The standard curve value was 25 – 5000 ng/mL and the linearity, inter-day and intra-day accuracy and precision were within 15.0 % of relative standard deviation (RSD). The mean recoveries of Jaspine B ranged from 87.5 % to 91.2 % with less than 3.70 % RSD and the matrix effects ranged from 91.1 % to 108.2 % with less than 2.6 % RSD. The validated LC-MS/MS analytical method of Jaspine B was successfully applied to investigate the dose-escalated pharmacokinetic study of Jaspine B in rats following an intravenous injection of Jaspine B at a dose range of 1 – 10 mg/kg. The initial plasma concentrations and area under plasma concentration curves showed a good correlation with intravenous Jaspine B dose, indicating the dose independent pharmacokinetics of Jaspine B in rats. In conclusion, this analytical method for Jaspine B can be easily applied in the bioanalysis and pharmacokinetic studies of Jaspine B, including its administration at multiple therapeutic doses, or for making pharmacokinetic comparisons for the oral formulations of Jaspine B in small experimental animals as well as in vivo pharmacokinetic–pharmacodynamic correlation studies.

    keywords
    jaspine B, liquid chromatography-tandem mass spectrometry, pharmacokinetics, rat, dose escalation


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