- P-ISSN 1225-0163
- E-ISSN 2288-8985
- 권한신청
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
논문 상세
Home > 논문 상세
Gliclazide compatibility with some common chemically reactive excipients; using different analytical techniques
분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2021, v.34 no.2, pp.46-55
https://doi.org/10.5806/AST.2021.34.2.46
(Tabriz University of Medical Sciences, Faculty of Pharmacy, Iran)
(Student Research Committee, Tabriz University of Medical Sciences. Iran)
(Tabriz University of Medical Sciences and NIMAD, Iran)
(Student Research Committee, Tabriz University of Medical Sciences. Iran)
(Tabriz University of Medical Sciences and NIMAD, Iran)
Hamideh,
N.
J.
,
Mohammad,
S.
,
&
Farnaz,
M.
(2021). . 분석과학, 34(2), 46-55, https://doi.org/10.5806/AST.2021.34.2.46
- 다운로드 수
- 조회수
Abstract
Evaluation of drug-excipient compatibility is one of the basic steps in the preformulation of pharmaceutical dosage forms. Some reactive excipients have been known so far which may cause stability problems for drug molecules in pharmaceutical dosage forms. The aim of this study was to evaluate drugexcipient compatibility of gliclazide with some common pharmaceutical excipients, known for their ability to incorporate in drug-excipient interactions. Binary mixtures were prepared using lactose, magnesium stearate, polyvinylpyrrolidone, sodium starch glycolate, polyethylene glycol 2000 and dicalcium phosphate. Based on the results; gliclazide was incompatible with all tested excipients; but not with dicalcium phosphate. DSC (Differential Scanning Calorimetry) results were in accordance with HPLC (High Pressure liquid chromatography) data and were more predictive than FTIR (Fourier Transform Infrared Spectroscopy). Drug and reactive excipients incompatibility was fully discussed and documented. It is advisable to avoid incompatible excipients or carefully monitor the drug stability when incorporating such excipients in final formulation designs.
- keywords
- incompatibility, excipient, gliclazide, differential scanning calorimetry, fourier transform infrared spectroscopy, high performance liquid chromatography
참고문헌
1
1. S. S. Bharate, S. B. Bharate and A. N. Bajaj, J. Excip. Food. Chem., 1(3), 3-26 (2010).
2
2. P. M. Adhikari and M. Pai, Journal of Clinical and Diagnostic Research, 1(5), 440-443 (2007).
3
3. F. Lotfipour, H. Valizadeh, S. Shademan and F. Monajjemzadeh, Iranian Journal of Pharmaceutical Research: IJPR, 14(4), 1015-1029 (2015).
4
4. F. Monajjemzadeh, F. Ebrahimi, P. Zakeri-Milani and H. Valizadeh, Adv. Pharm. Bull., 4(4), 329-338 (2014).
5
5. M. R. S. Shadbad, F. Ghaderi, L. Hatami and F. Monajjemzadeh, AAPS PharmSciTech, 17, 1491-1499(2016).
6
6. S. K. Sharma, S. Mohan, M. Jaimini, B. S. Chauhan and A. Chatterjee, International Journal of PharmTech Research, 6(2), 607-622 (2014).
7
7. F. Ghaderi, M. Nemati, M. R. Siahi-Shadbad, H. Valizadeh and F. Monajjemzadeh, Journal of Thermal Analysis and Calorimetry, 123(3), 2081-2090 (2016).
8
8. F. Monajjemzadeh and F. Ghaderi, J. Mol. Pharm. Org. Process Res., 3, e121 (2015).
9
9. G. Kirtansinh, P. Piyushbhai and P. Natubhai, International Journal of Pharmaceutical & Biological Archive, 2(5), 1319-1326 (2011).
10
10. R. C. Rowe, P. J. Sheskey and P. J. Weller, ‘Handbook of Pharmaceutical Excipients’, 6th Ed, Pharmaceutical press, London, 2006.
11
11. A. T. Serajuddin, A. B. Thakur, R. N. Ghoshal, M. G. Fakes, S. A. Ranadive, K. R. Morris and S. A. Varia, Journal of Pharmaceutical Sciences, 88(7), 696-704(1999).
12
12. F. Monajjemzadeh and A. Farjami, Journal of Molecular Pharmaceutics & Organic Process Research, 2(3), e117 (2014).
13
13. F. Monajjemzadeh, D. Hassanzadeh, H. Valizadeh, M. R. Siahi-Shadbad, J. S. Mojarrad, T. A. Robertson, et al., Pharmind: Die Pharmazeutische Industrie, 73(1), 174-177 (2011).
14
14. F. Monajjemzadeh, D. Hassanzadeh, H. Valizadeh, M. R. Siahi-Shadbad, J. S. Mojarrad, T. A. Robertson, et al., European Journal of Pharmaceutics and Biopharmaceutics, 73(3), 404-413 (2009).
15
15. F. Ghaderi, M. Nemati, M. R. Siahi-Shadbad, H. Valizadeh and F. Monajjemzadeh, Journal of Food and Drug Analysis, 25(3), 709-716 (2017).
16
16. F. Ghaderi, M. Nemati, M. R. Siahi-Shadbad, H. Valizadeh and F. Monajjemzadeh, Journal of Thermal Analysis and Calorimetry, 130(3), 1417-1427 (2017).
17
17. G. Bansal, M. Singh and K. C. Jindal, Chromatographia, 66(9-10), 751-755 (2007).
18
18. S. K. Branch, Journal of Pharmaceutical and Biomedical Analysis, 38(5), 798-805 (2005).
19
19. M. Windholz, S. Budavari, L. Y. Stroumtsos and M. N. Fertig, ‘The Merck Index: An Encyclopedia of Chemicals and Drugs’, 15th Ed, Royal Society of Chemistry, London, UK, 2013.
20
20. P. Niguram, S. N. Polaka, R. Rathod, K. Kalia and A. S. Kate, Drug Development and Industrial Pharmacy, 46(2), 209-218 (2020).
21
21. M. Ecaterina, S. Martin and U. Livia, The Moldovan Medical Journal, 63(4), 35-42 (2020).
22
22. Y. Wu, J. Levons, A. S. Narang, K. Raghavan and V. M. Rao, AAPS PharmSciTech, 12(4), 1248-1263 (2011).
권호 내 다른 논문
- Development of Jaspine B analysis using LC-MS/MS and its application: Dose-independent pharmacokinetics of Jaspine B in rats
- Gliclazide compatibility with some common chemically reactive excipients; using different analytical techniques
- A preliminary study of semi-quantitative, comparative evaluation of split or half fingerprints using Densitometric Image Analysis (DIA) - Inter-analyst differences for split or half fingerprints -
- Development and validation of a qualitative GC-MS method for THCCOOH in urine using injection-port derivatization
- Determination of cut-off value by receiver operating characteristic curve of norquetiapine and 9-hydroxyrisperidone concentrations in urine measured by LC-MS/MS
- Development of a nanoparticle multi-generator for assessment of inhalation hazard
- more
추천 논문
학술지 홈페이지 이용 환경은 크롬 브라우저 사용을 권장합니다.