- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Investigation of in vivo Synergism of Mawhangyounpye-tang, a poly-herbal formula and ciprofloxacin against Streptococcus pneumoniae respiratory infection
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.2, pp.13-24
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(2005). Investigation of in vivo Synergism of Mawhangyounpye-tang, a poly-herbal formula and ciprofloxacin against Streptococcus pneumoniae respiratory infection. Journal of Korean Medicine, 26(2), 13-24.
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Abstract
Objectives & Methods : In order to evaluate the in vivo synergic effect of Mawhangyounpye-tang which was a traditional poly-herbal formula has been used in the treatment of respiratory diseases in Korea, with quinolone antibiotic, ciprofloxacin(CPFX), the viable bacterial number and histopathological changes were monitored after experimental respiratory infection with Streptococcus pneumoniae ATCC 6303. Results : 1. In CPFX groups, the viable bacterial numbers were significantly decreased compared to that of Control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Mawhangyounpye-tang. 2. In Control group, severe infiltration of inflammatory cells, hemorrhage and hypertrophy of alveolar linings were demonstrated at microscopical levels. However, these abnormal histopathological changes were significantly decreased compared to that of Control group in CPFX groups, and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Mawhangyounpye-tang. 3. In CPFX groups, the LSA(luminal surface of alveoli %) were significantly increased compared to that of Control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Mawhangyounpye-tang. Conclusion : According to these results, it is considered as the in vivo antibacterial activity of CPFX was dramatically increased by concomitant use of Mawhangyounpye-tang against Streptococcus pneumoniae ATCC 6303 infection of respiratory tract.
- keywords
- ciprofloxacin(CPFX), Streptococcus pneumoniae, Mawhangyounpye-tang(麻黃潤肺湯), ciprofloxacin(CPFX), Streptococcus pneumoniae, Mawhangyounpye-tang(麻黃潤肺湯)
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